Активность основных карбокмипептидаз в тканях пренатально алкоголизированных крыс

Влияние хронической алкоголизации на организм. Влияние пренатального хронического воздействия этанола на организм. Ферменты обмена регуляторных пептидов. ФМСФ-ингибируемая карбоксипептидаза. Регуляторные пептиды и ферменты их обмена в онтогенезе.

Рубрика Биология и естествознание
Вид диссертация
Язык русский
Дата добавления 15.12.2008
Размер файла 219,2 K

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89. Сатановская О.А. Окисление этанола // Вопр. мед. химии - 1991. - 114, №5. - С. 573-580.

90. Скосырева А.М., Балика Ю.Д., Картамышева В.Е. Влияние этилового алкоголя на развитие эмбриона в эксперименте // Акушерство и гинекология. - 1981. - № 1. -С. 38-40.

91. Сторожок С. А., Панченко Л. Ф., Филиппович Ю. Д., Глушков В. С. Изменения физико-химических свойств биологических мембран при развитии толерантности к этанолу. // Вопр. мед. химии. - 2001. №2. - С. 23-28.

92. Сторожок С.А. Содержание гидроперекисей в липидах, активность супероксидисмутазы и глюкозо-6-фофсатдегидрогеназы эритроцитов при алкогольной интоксикации // Вопр. мед. химии - 1983. - 29, № 6. - С. 31-34.

93. Судаков К.В. Геном и олигопептиды в системных механизмах обучения // Третьи Павловские чтения, Рязань. - 1989. - С. 3.

94. Сухоруков В.С., Тарабрин С. Б. Роль пролактила в регуляции функций мужской гонады // Усп. совр. биол. - 1993. - 113, № 3. - С. 366-376.

95. Тинников А.А. Роль гипоталамо-гипофизарно-надпочечниковой системы в регуляции полового развития // Усп. совр. биол. - 1990. - 110, № 3(6). - С. 419-428.

96. Троицкий Г. В., Багдасарян С. Н. // Вопр. мед. химии - 1987, - 33, №2,. - С. 38-42.

97. Усатенко М. C., Петрова М. А., Матвеева М. М. и др. Динамика активности ферментов - маркеров системного употребления алкоголя в крови больных алкоголизмом // Вопр. наркологии. - 1991. №4. - С. 9-12.

98. Хоха А. М. Угнетение этанолом биосинтеза половых гормонов и гипоталамо-гипофизарно-надпочечниковая система // Вопр. мед. химии - 1994. - 114, №5. - С. 573-580.

99. Чиркова С.К., Войт И.С. Влияние алкоголя на развитие острых эмоционально-стрессорных состояний у обезьян // Жур. высш. нервн. деят. - 1990. - 40, № 3. - С. 585-587.

100. Щетинина Н.В. Активность основных карбоксипептидаз в тканях и отделах мозга крыс в онтогенезе: Автореф. дис….канд. биол. наук. - СПб., 1997 - 20 с.

101. Щетинина Н.В., Вернигора А.Н., Генгин М.Т. Активность основных карбоксипептидаз у крыс разного пола // Укр. биохим. журн. - 1997. - 70, № 3. - С. 110-113.

102. Щетинина Н.В., Вернигора А.Н., Генгин М.Т., Фирстова Н.В. Тканевое и региональное распределение активности фенилметилсульфонилфторид-ингибируемой карбоксипептидазы и других карбоксипептидаз у крыс // Укр. биохим. журн. - 1997. - 70, № 3. - С. 23-28.

103. Эндорфины: Пер. с англ. / Под ред. Э.Коста, М. Трабукки. Перевод Панова М.А.; Под ред. В.Б.Розена - М.: Мир, 1981. - 368 с.

104. Янский Л., Выбирал С. , Романовский А.А., Гурин В.Н Механизм влияния нейропептидов на терморегуляцию // Нейропептиды и терморегуляция / Под ред. В.Н. Гурина, Минск. - 1990. - С. 9.

105. Aasmoe L., Aarbakke J. Sex dependent induction of alcohol-dehydrogenase activity in rats // Biochem. Pharmacol. - 1999. - 57, N 9. - P. 1067-1072.

106. Adams N., Oldham T.D., Briscoe J.T., Hannah J.A., Blizard D.A. Ethanol preference in maudsley and RXNRA recombinant inbred strains of rat // Alcohol - 2001. - 24, N 1. - P. 25-34.

107. Agarwal D. P., Goedde H. W. Aldehyddehydrohenazes of human: genetiсs reason a different sens: tiveness to alсohol // Genet. Biol. Alсoholism. - 1990. - С. 253-261.

108. Aguilardiosdado M., Parkinson D., Corbett J. A., Kwon G., Marshall C. A., Gingerich R. L., Santiago J. V., Mcdaniel M. L. Potential autoantigens in IDDM - expression of carboxypeptidase H and insulin but not glutamatedecarboxylase on the beta-cellsurface // Diabetes. - 1994. - 43, N 3. - P. 418-425.

109. Aird F., Halasz I., Redei E. Ontogeny of hypothalamic corticotropin-releasing factor and anterior pituitary proopiomelanocortin expression in male and female offspring of alcohol exposed and adrenalectomized dams // Alcohol. Clin. Exp. Res. - 1997. - 21, N 9. - P. 1560-1566.

110. Alcalde L., Tonacchera M., Costagliola S., Jaraquemada D., Pujol Borrell R., Ludgate M. Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH // J. Autoimmunity. - 1996. - 9, N 4. - P. 525-528.

111. Allan A.M., Weeber E.J., Savage D.D., Caldwell K.K. Effects of prenatal ethanol exposure on phospholipase C- beta-1 and phospholipase A(2) in hippocampus and medial frontal cortex of adult rat offspring // Alcohol. Clin. Exp. Res. - 1997. - 21, N 8. - P. 1534-1541.

112. Alling C., Gustavsson L., Hansson E., Ronnback L. Lipids and fatty acids in membranes from astroglial cells cultured in ethanol-containing media. // Drug. Alсohol. Depend. - 1986. - 18, N 2. - P. 115-126.

113. Almeida O.F.X., Shoaib M., Deicke J., Fischer D., Darwish M.H., Patchev V.K., Gender differences in ethanol preference and ingestion in rats - the role of the gonadal-steroid environment // J. Clin. Invest. - 1998. - 101, N 12. - P. 2677-2685.

114. Angelucci F., Fiore M., Cozzari C., Aloe L. Prenatal ethanol effects on NGF level, NPY and chat immunoreactivity in mouse entorhinal cortex - a preliminary-study // Neurotoxicol. Teratol. - 1999. - 21, N 4. - P. 415-425.

115. Azaryan A.V., Hook V.Y.H. Unique cleavage specificity of prohormone thiol protease related to proenkephalin processing // FEBS Lett. - 1994. - 341, N 2-3. - P. 197-202.

116. Bader M.F., Simon J.P., Sontag J.M,. Langley K., Aunis D. Role of calcium in secretion and synthesis in bovine adrenal chromaffin cells // Adv. Exp. Med. Biol. - 1990. - 269. - P. 93-97.

117. Barry R. E., McGivan J.D. Acetaldehyde alone may initiate hepatocellular damage in acute alcoholic liver disease // Gut. - 1985. - 26, N 10. - P. 1065-1069.

118. Bayon A., Shoemaker W.S., Bloom F.E., Mauss A., Guillemin R. Perinatal development of the endorphin and enkephalincontaining systems in the rat brain // Brain Res. - 1979. - 179. - P. 93-101.

119. Beinfeld M.C., Korchak D.M., Nilaver G., O'Dorisio T.M. The development of motilin, cholecystokinin and vasoactive intestinal polypeptide in the forebrain and hindbrain of the rat, as determined by radioimmuno assay // Der. Brain. Res. - 1983. - 10. - P. 146-150.

120. Bell S. M.,·Reynolds J. G., Thiele T. T., Gan J., Figlewicz D. P., Woods S. C. Effects of third intracerebroventricular injections of corticotropin-releasing factor (CRF) on ethanol drinking and food intake // Psychopharmacology - 1998. V. 139. - P. 128-135.

121. Bellparikh L. C., Eipper B. A., Mains R. E. Response of an integral granule membrane protein to changes in pH. // J. Biol. Chem. - 2001. - 276, N 32. P. 29854-29863.

122. Beresford T., Arciniegas D., Rojas D., Sheeder J., Teale P., Aasal R., Sandberg E., Reite M. Hippocampal to pituitary volume ratio: a specific measure of reciprocal neuroendocrine alterations in alcohol dependence // J. Stud. Alcohol. - 1999. - 60, N 5. - P. 586-588.

123. Bidder M., Weizman R., Fares F., Grel I., Gavish M. Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs // Biochem. Pharmacol. - 1992. - 44, N 7. - P. 1335-1339.

124. Birch N.P., Rodriguez C., Dixon J.E., Mezey E. Distribution of carboxypeptidase H messenger RNA in rat brain using in situ hybridization histochemistry: implications for neuropeptide biosynthesis // Brain Res. Mol. Brain Res. - 1990. - 7, N 1. - P. 53-59.

125. Blum H. Alсohol and сentral nervous system peptides. // Supst. Alсohol Aсt. Misuse. - 1983. - 4, N 2-3. - P. 73-78.

126. Bommer M, Nikolarakis K, Noble E.P, Herz A. In vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of gua-nidinoethylmercaptosuccinic acid (GEMSA) possible physiological role of enkephalin convertase // Brain Res. - 1989. - 492, N 1/2. - P. 305-313.

127. Bonten E.J, Galjart N.J, Willemsen R, Usmany M, Vlak JM, d'Azzo A. Lysosomal protective protein/cathepsin A. Role of the "linker" domain in catalytic activation // Biol Chem. - 1995. - 270, N 44. - P. 26441-26445.

128. Boyadjieva N., Meadows G., Sarkar D. Effects of ethanol consumption on Я-endorphin levels and natural killer cell activity in rats // Ann. New York Acad. Sci. - 1999. N. 885. - P. 383-386.

129. Brust P., Bech A., Kretzschmar R., Bergmann R. Developmental changes of enzymes involved in peptide degradation in isolated rat brain microvessels // Peptides. - 1994. - 15, № 6. - P. 1085-1088.

130. Burd L., Martsolf J.T. Fetal alcohol syndrome variability // Physiol. Behav. - 1989. - 46, N 1. - P. 39-43.

131. Bures E. J., Courchesne P. L., Douglass J., Chen K., Davis M. T., Jones M. T., Jones M. D., Mcginley M. D., Robinson J. H., Spahr C. S., Sun J. L., Wahl R. C., Patterson S. D. Identification of incompletely processed potential carboxypeptidase-E substrates from Cpefat/Cpefat mice. // Proteomics. - 2001. - 1, N 1. P. 79-92.

132. Butters N.S., Gibson M.A.S., Reynolds J.N., Brien J.F. Effects of chronic prenatal ethanol exposure on hippocampal glutamate release in the postnatal guinea pig // Alcohol - 2000. - 21, N 1. - P. 1-9.

133. Carter A., Soliman.M.R.I. Estradiol and progesterone alter ethanol induced effects on м-opioid receptors in specific brain regions of ovariectomized rats // Life Sci. - 1997. - 62, N 2. - P. 93-101.

134. Castoldi A.F., Barni S., Randine G., Costa L.G., Manzo L. Ethanol selectively interferes with the trophic action of NMDA and carbachol on cultured cerebellar granule neurons undergoing apoptosis // Develop. Brain Res - 1998. - 111, N 2. - P. 279-289.

135. Charness M. F. Ethanol and opioid reсeptor signalling // Experientia. - 1989. - 45, N 5. - P. 418-428.

136. Che F. Y., Yan L., Li H., Mzhavia N., Devi L. A., Fricker L. D., Identification of peptides from brain and pituitary of Cpe(Fat)/Cpe(Fat) mice. // Proc. Nat. Acad. Sci. USA. - 2001. - 98, N 17. P. 9971-9976.

137. Chen H. Jawahar S., Qian Y. M., Duong Q. Y., Chan G. Y., Parker A., Meyer J. M., Moore K. J., Chayen S., Gross D. J., Glaser B., Permutt M. A., Fricker L. D. Missense polymorphism in the human carboxypeptlidase-E gene alters enzymatic activity. .// Hum. Mutat. - 2001. - 18, N 2. P. 120-131.

138. Conway S., Ling S.Y., Leidy J.W., Blaine K., Holtzman T., Effect of fetal ethanol exposure on the in vitro release of growth hormone, somatostatin and growth hormone - releasing factor induced by clonidine and growth hormone feedback in male and female rats // Alcohol. Clin. Exp. Res. - 1997. - 21, N 5. - P. 826-839.

139. Cool D.R., Loh Y.P. Carboxypeptidase E is a sorting receptor for prohormones - binding and kinetic studies // Mol. Cell. Endocrinol. - 1998. - 139, N 1-2, P. 7-13.

140. Cool D.R., Normant E., Shen F.S., Chen H.C., Pannell L., Zhang Y., Loh Y.P. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(Fat) mice // Cell. - 1997. - 88, N 1, P. 73-83.

141. Crippens D., White M.L., George M.A., Jaworski J.N., Brunner L.J., Lancaster F.E., Gonzales R.A. Gender differences in blood levels, but not brain levels, of ethanol in rats // Alcohol. Clin. Exp. Res. - 1999. - 23, N 3. - P. 414-420.

142. Dakes M.J., Davis T.P. The ontogeny of enzymes involved in posttranslational processing and metabolism of neuropeptides // Dev. Brain Res. - 1994. - 80, N 1-2, P. 127-136.

143. Daniel M.A., Evans M.A. Quantitative comparison of maternal ethanol and maternal tertiary butanol diet on postnatal development // J. Pharmacol. Exp. Ther. - 1982. - 222, N 2. - P. 294-300.

144. Das B., Sablan E.L., Kilbourne E.J., Fricker L.D. Regulation of carboxypeptidase E by membrane depolarization in PC12 pheochromocythoma cells: comparison with the mRNA's encording other peptide and catecholamine's biosynthetic enzymes // Neurochem. - 1992. - 59, N 6. - P. 2263-2270.

145. Davidson H.W., Hutton J.C. The insulin-secretory-granule carboxypeptidase H: Purification and demonstration of involvement in proinsulin processing // Biochem. J. - 1987. - 245, N 2. - P. 575-582.

146. Davis T. P., Gulling-Berglund A. S., Gillespie T. S., Smith T. L. Ethanol treatment alters Я-endorphin metabolism by purified synaptosomal plasma membranes. // Peptides. - 1987. - 8, N 3. - P. 467-472.

147. Demmer W., Brand K. Carboxypeptidase activity in synaptic vesicles isolated from striatum and cortex of calf brain // Arch. Biochem. Biophys. - 1985. - 239, N 2. - P. 375-378.

148. Devaud L.L., Chadda R., Sex-differences in rats in the development of and recovery from ethanol dependence assessed by changes in seizure susceptibility // Alcohol. Clin. Exp. Res. - 2001. - 25, N 11. - P. 1689-1696.

149. Devaud L.L., Fritschy J.M., Morrow A.L. Influence of gender on chronic ethanol induced alterations in GABA(A) receptors in rats // Brain Res. - 1998. - 796, N 1-2. - P. 222-230.

150. Dhanvantari S., Loh Y. P. Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor. // J. Biol. Chem. -2000. - 275, N 38. P. 29887-29893.

151. Dochetry K., Hutton J.C. Carboxypeptidase activity in the insulin secretory granule // FEBS Lett. - 1983. - 162, N 1. - P. 137-141.

152. Dronou A., Lucas D., Powell L.W. // Clin. Chem. - 1985. - 31, N 9. - P. 1543-1546.

153. Druse M.J., Hao H.L., Eriksen J.L. In utero ethanol exposure increases proenkephalin, a precursor of a neuropeptide that Is inhibitory to neuronal growth // Alcohol. Clin. Exp. Res. - 1999. - 23, N 9. - P. 1519-1527.

154. Du X.P., Hamre K.M. Increased cell death in the developing vestibulocochlear - ganglion complex of the mouse after prenatal ethanol exposure // Teratology - 2001. - 64, N 6. - P. 301-310.

155. Dufouil C., Ducimetiere P., Alperovitch A., Sex-differences in the association between alcohol consumption and cognitive performance // Amer. J Epidemol. - 1997. - 146, N 5. - P. 405-412.

156. Dulka J.G., Maler L., Ellis W. Androgen-induced changes in electrocommunicatory behavior are correlated with changes in substance P-like immunoreactivity in the brain of the electric fish Apteronotus leptorhynchus // J. Neurosci. - 1995. - 15, № 3 (Pt.1). - P. 1879-1890.

157. Eipper B.A, Green C.B, Mains R.E. Expression of prohormone processing enzymes in neuroendocrine and non neuro-endocrine cells // Monogr. Natl. Cancer. Inst. - 1992. - 13, P. 163-168.

158. Ekstrom J., Ekman R., Hakanson R., Luts A., Sundler F. Developmental studies on vasoactive intestinal peptide, substance P and caleifonin generelated peptide in salivary glands of postnatal rats // Acta Physiol. Scand. - 1994. - 151, № 1. - P. 107-115.

159. Emson P.C., Gilbert R.F.T., Lorer I., Fakrenkrung J., Sundler F., Schaffalitzky de Muckadell O.B. Development of vasoactive intestinal polypeptide (VIP) containing neurons in the rat brain // Brain Res. - 1979. - 177. - P. 437-444.

160. Feng Y., Reznik S. E., Fricker L. D. Distribution of proSAAS derived peptides in rat neuroendocrine tissues. // Neurosci. - 2001. - 105, N 2. P. 469-478.

161. Fiedorek F.T Jr, Parkinson D. Carboxypeptidase H processing and secretion in rat clonal beta cell lines // Endocrinology. - 1992. - 131, N 3. - P. 1054-1062

162. Foster G.A., Schultzbeng M. Immunohistochemical analysis of the ontogeny of neuropeptide Y immunoreactive neurons in foctal rat brain // Int. J.Dev.Neurosci. - 1994. - 2. - P. 387-407.

163. Fricker L.D. Carboxypeptidase E // Ann. Rev. Physiol. - 1988. - 50. - P. 309-321.

164. Fricker L.D. Neuropeptide biosynthesis: focus on carboxypeptidase processing enzyme // Trends Neurosci. - 1985. - 8, № 5. Р. 210-214.

165. Fricker L.D., Adelman J.P., Douglass J., Thompson R.C, von Strandmann R.P, Hutton J AD. Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme // Mol. Endocrinol. - 1989. - 3, N 4. - P. 666-673.

166. Fricker L.D., Das B., Angeletti R.H. Identification of the pH dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10) // J. Biol. Chem. - 1990. - 265, N 5. - P. 2476-2282.

167. Fricker L.D., Devi L. Posttranslational processing of carboxypeptidase E, a neuropeptide processing enzyme, in AtT 20 cells and bovine pituitary secretory granules // J. Neurochem. - 1993. - 61, N 4. - P. 1404-1415.

168. Fricker L.D., Herbert E. Comparison of a carboxypeptidase E-like enzyme in human, bovine, mouse, Xenopus, shark and Aplysia neural tissue // Brain Res. - 1988. - 453, N 1-2. - P. 281-286.

169. Fricker L.D., Plummer T.H., Snyder S.H. Enkephalin convertase: potent, selective and irreversible inhibitors // Biochem. and Biophys. Res. Commun. - 1983. - 11, N 3. - P. 994-1000.

170. Fricker L.D., Reaves B.J., Das B., Dannies P.S. Comparison of the regulation of carboxypeptidase E and prolactin in GH4C1 cells, a rat pituitary cell line. // Neuroendocrinology. - 1990. - 51, N 6. - P. 658-663.

171. Fricker L.D., Rigual R. J., Diliberto E. J. Jr., Viveros O. H. Reflex spanchnic nerve stimulation increases levels of carboxypeptidase-E mRNA and enzymatic activity in the rat adrenal medulla // J. Neurochem. - 1990. - 55, N 2. - P. 461-467.

172. Fricker L.D., Snyder S.H. Enkephalin convertase: purification and charasterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenall chromaffin granules // Proc. Natl. Acad. Sci. USA. - 1982. - 79. - P. 3886-3890.

173. Fricker L.D., Snyder S.H. Purification and characterization of enkephalin convertase, an enkephaline-synthesizing carboxypeptidase // J. Biol. Chem. - 1983. - 79. P. 33886-3890.

174. Fricker L.D., Supattapone S., Snyder S.H. Enkephalin convertase: a specific enkephalin synthesing carboxypeptidase in adrenal chromaffin granules, brain and pituitary gland // Life Sci. - 1982. - 31. - P. 1841-1844.

175. Friishansen L., Lacourse K. A., Samuelson L. C., Holst J. J. Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E deficient mice. // J. Endocrinol. - 2001. - 169, N 3. P. 595-602.

176. Friksen S.P., Kulkarni A.B. Methanol in normal human breath // Science - 1963. - 141. - P. 639-640.

177. Gabriel K.I., Yu W., Ellis L., Weinberg J. Postnatal handling does not attenuate hypothalamic- pituitary-adrenal hyperresponsiveness after prenatal ethanol exposure // Alcohol. Clin. Exp. Res. - 2000. - 24, N 10. - P. 1566-1574.

178. Gabriel K.I., Weinberg J. Effects of prenatal ethanol exposure and postnatal handling on conditioned taste-aversion // Neurotoxicol. Teratol. - 2001. - 23, N 2. - P. 167-176.

179. Gandarias J.M., Irazusta J., Fernandez D., Silio M., Casis L. Membrane-bound pyroglutamyl-arylamidase activity during the first postnatal month in several rat brain areas // Int. J. Dev. Biol. - 1994. - 38, № 1. - P. 127-129.

180. Gandarias J.M., Ramirez M., Zulaica J., Casis L. Aminopeptidase (arylamidase) activity in discrete areas of the rat brain: Sex differences // Horm. Metab. Res. - 1989. - 5, № 21. - P. 285-286.

181. Genazzani A.R., Faechinetti F., Petraglia F., Pintor C., Bagnoli F., Puggioni R., Corda R. Correlations betneen plasma levels of opioid peptides and adrenal androgens in prepuberty and puberty // J. Steroid. Biochem. - 1983. - 19, № 1. - P. 891-895.

182. Glavas M.M., Hofmann C.E., Yu W.K., Weinberg J. Effects of prenatal ethanol exposure on hypothalamic-pituitary-adrenal regulation after adrenalectomy and corticosterone replacement // Alcohol. Clin. Exp. Res. - 2001. - 25, N 6. - P. 890-897.

183. Glombik M. M., Kromer A., Salm T., Huttner W. B., Gerdes H. H. The disulfide-bonded loop of chromogranin-B mediates membrane-binding and directs sorting from the trans-Golgi network to secretory granules. // EMBO J. - 1999. - 18. 4. P. 1059-1070.

184. Goldstein D. B., Chim Y. H. Interaktion of ethanol with biological membranes. // Fed. Proc. - 1981. - 40, N 7. - P. 2073-2076.

185. Gorenstein C., Snyder S., Tmo distinct enkephalinases solupilizabion, partial purification and separation from angiotensin converting enzyme // Life. Sci. - 1979. - 25. - P. 2065.

186. Graham K., Wilsnack R., Dawson D., Vogeltanz N. Should alcohol consumption measures be adjusted for gender differences // Addiction - 1998. - 93, N 8. - P. 1137-1147.

187. Grigoriants O., Devi L., Fricker L.D. Dopamine antagonist haloperidol increases carboxypeptidase E mRNA in rat neurointer-mediate pituitary but not in various other rat tissues // Mol. Brain Res. - 1993. - 19. - P. 161-164.

188. Grimwood B.G., Plummer T.H. Jr., Tarentino A.L. Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells // J. Tiolog. Chem. - 1989. - 264, N 26. - P. 15662-15667.

189. Guaza C., Borrell S. Modifications in adrenal hormones response to ethanol by prior ethanol dependence // Pharmacol. Biochem. Behav. - 1985. - 22, N 3. - P. 357-360.

190. Guerri C. Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure // Alcohol. Clin. Exp. Res. - 1998. - 22, N 2. - P. 304-312.

191. Guerri C., Renaupiqueras J. Alcohol, astroglia, and brain development // Mol. Neurobiol. - 1997. - 15, N 1. - P. 65-81.

192. Guest P.C., Arden S.D., Rutherford N.G., Hutton J.C. The posttranslational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans // Mol. Cell. Endocrinol. - 1995. - 113, N 1, P. 99-108.

193. Guest P.C., Ravazzola M., Davidson H.W., Orci L., Hutton J.C. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans // Endocrinology. - 1991. - 129, N 2. - P. 734-740.

194. Hall C.S. Emotional behavior in the rat. The relationship between emotionality and ambulatory activity // J. Copm. Physiol. Psychol. - 1936. - 22. - P. 345-352.

195. Hanna W.L., Turbov J.M., Jackman H.L., Tan Fulong, Froelich C.J. Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein // Immunol. - 1994. - 153, N 10, - P. 4663-4672.

196. Hansen L. F., Rehfeld J. F. Impaired feedback of gastric functions in carboxypeptidase E deficient mice // Biochem. and Biophysic. Res. Comm. - 2000. - 267, N 2. P. 638-642.

197. Harada S., Tachiyashiki K., Imaizumi K. Effect of sex-hormones on rat-liver cytosolic alcohol dehydrogenase activity // J Nutr. Sci. Vitaminol. - 1998, - 44, N 5, P. 625-639.

198. Hitсhison W. D., Gianoulakis С., Kalant H. Effeсt of ethanol withdrawal on Я - endorphin levels in rat brain and pituitary. // Pharm. Bioсhem. Behav. - 1988. - 30, N 4. - P. 933-939.

199. Hook V.Y. Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme // Life Sci. - 1990. - 47, N 13. - P. 1135-1139.

200. Hook V.Y. Carboxypeptidase B-like activity for the processing of enkephalin precursors in the membrane component of bovine adrenomedullary chromaffin granules // Neuropeptides. - 1984. - 4, N 2. - P. 117-126.

201. Hook V.Y., Affolter H.U., Palkovits M. Carboxypeptidase H in the hypothalamo neurohypophysial system: evidence for processing and activation of a prohormone processing enzyme during axonal transport // J. Neurosci. - 1990. - 10, N 10. - P. 3219-3226.

202. Hook V.Y., LaGamma E.F. Product inhibition of carboxypeptidase H // J. Biol. Chem. - 1987. - 262, N 26. - P. 12583-12588.

203. Hook V.Y., Lee E.E. Two peptidases that convert 125J-Lys-Arg-(Met)-enkephalin and 125J-enkephalin-Arg6, respectively, to 125J-(Met)-enkephalin in bovine adrenal medullary chromaffin granules // FEBS Lett. - 1984. - 172, N 2. - P. 212-218.

204. Hook V.Y., Loh Y.P. Carboxypeptidase B-like convertasing enzyme activity in secretory granules of rat pituitary // Cell Biol. - 1984. - 81. - P. 2776-2780.

205. Hook V.Y., Mezey E., Fricker L.D., Pruss R.M., Siegel R.E., Brownstein M.J. Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzymes // Proc. Natl. Acad. Sci. USA. - 1982. - 82. - P. 4745-4749.

206. Hook V.Y.H., Affolter H.U. Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones // FEBS Lett. - 1988. - 238, N 2. - P. 338-342.

207. Hook V.Y.H., Eiden L. E. Two peptidases that convert 125J-Lys-Arg-(Met)-enkephalin and 125J-enkephalin-Arg6, respectively, to 125J-(Met)-enkephalin in bovine adrenal medullary chromaffin granules // FEBS Let. - 1984. - 172, N 2. - P. 212-218.

208. Hughes P.D., Kim Y.N., Randall P.K., Leslie S.W. Effect of prenatal ethanol exposure on the developmental profile of the NMDA receptor subunits in rat forebrain and hippocampus // Alcohol. Clin. Exp. Res. - 1998. - 22, N 6. - P. 1255-1261.

209. Inder W.J., Joyce P.R., Ellis M.J., Evans M.J., Livesey J.H., Donald R.A The effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptides // Clin. Endocrinol. - 1995. - 43, N 3. - P. 283-290.

210. Irminger J.C., Verchere C.B., Meyer K., Halban P.A. Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E deficient Cpe(Fat)/Cpe(Fat) mice // J. Biol. Chem. - 1997. - 272, N 44, P. 27532-27534.

211. Isenberg K.T., Bora P.S., Zhou Xia, Wu Xiaolin, Moore B. W., Lange L. G. Nonoxidative ethanol metabolism: expression of fatty aсid ethyl ester synthase-III in сultured neural сells. // Bioсhem. Biophys. Res. Сommun. - 1992. - 185, N 3. - P. 938-943.

212. Iversen I., Turner A. Neuropeptides and their peptidases: functional consideration // Neurochem. Intern. - 1987. - 12. - P. 383-387.

213. Jin K. L., Graham S. H., Nagayama T., Goldsmith P. C., Greenberg D. A., Zhou A., Simon R. P. Altered expression of the neuropeptide processing enzyme carboxypeptidase-E in the rat brain after global ischemia. // J. Cerebr. Blood Flow Metabol. - 2001. - 21. N 12. P. 1422-1429.

214. Juarez J., Detomasi E.,B. Sex differences in alcohol drinking patterns during forced and voluntary consumption in rats // Alcohol - 1999. - 19, N 1. - P. 15-22.

215. Jung M.E., Wallis C.J., Gatch M.B., Lal H. Sex differences in the pentylenetetrazol-like stimulus- induced by ethanol withdrawal // J Pharmacol. Exp. Ther. - 1999. - 291, N 2. - P. 576-582.

216. Jung M.E., Wallis C.J., Gatch M.B., Lal H. Sex-differences in nicotine substitution to a pentylenetetrazol discriminative stimulus during ethanol withdrawal in rats // Psychopharmacology - 2000. - 149, N 3. - P. 235-240.

217. Jung M.E., Wallis C.J., Gatch M.B., Lal H. Sex-differences in the discriminative stimulus effects of M-chlorophenylpiperazine and ethanol withdrawal // Psychopharmacology - 2000. - 149, N 2. - P. 170-175.

218. Jung Y.K., Fricker L. D. Expression of the carboxypeptidase-E gene - characterization of the initiator-binding proteins // Biochimie. - 1994. - 76. N 3-4. - P. 336-345.

219. Jung Y.K., Kunczt C.J., Pearson R.K., Dixon J.E., Fricker L.D. Structural characterization of the rat carboxypeptidase-E gene. // Mol. Endocrinol. - 1991. - 5, N 9. - P. 1257-1268.

220. Jung Y.K., Kunczt C.J., Pearson R.K., Fricker L.D., Dixon J.E. Expression of the rat carboxypeptidase-E gene in neuroendocrine and nonneuroendocrine cell lines // Mol. Endocrinol. - 1992. - 6, N 12. - P. 2027-2037.

221. Juvvadi S., Fan X.M., Nagle G.T., Fricker L.D. Characterization of aplysia carboxypeptidase E // FEBS Lett. - 1997. - 408, N 2, P. 195-200.

222. Keith L.D., Crabbe J.C., Robertson L.M., Young E.R. Ethanol dependence and the pituitary adrenal axis in mice. II. Temporal analysis of dependence and withdrawal // Life Sci. - 1983. - 33, N 19. - P. 1889-1897.

223. Kenney W. C. Formation of Schiff base adduct between acetaldehyde and rat liver microsomal phosphatidylethanolamine. // Alcohol. Clin. Exp. Res. - 1984. - 8, N 6. - P. 551-555.

224. Kim C.K., Yu W., Edin G., Ellis L., Osborn J.A., Weinberg J. Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol // Psychoneuroendocrinology - 1999. - 24, N 6. - P. 585-611.

225. Kimura K.A., Chiu J., Reynolds J.N., Brien J.F. Effect of chronic prenatal ethanol exposure on nitric oxide synthase-I and synthase-III proteins in the hippocampus of the near term fetal guinea pig // Neurotoxicol. Teratol. - 1999. - 21, N 3. - P. 251-259.

226. Kimura K.A., Reynolds J.N., Brien J.F. Ethanol neurobehavioral teratogenesis and the role of the hippocampal glutamate-N-methyl-D-aspartate receptor - nitric oxide synthase system // Neurotoxicol. Teratol. - 2000. - 22, N 5. - P. 607-616.

227. King J.C., Fabro S. Alcohol counsumption and cigarette smoking: effect on pregnancy // Clin. Obstet. Gynecol. - 1983. - 26. - P. 437-448.

228. Kinoshita, Jessop/

229. Klein R. S., Das B., Fricker L. D. Secretion of carboxypeptidase E from cultured astrocytes and from AtT-20 cell, a neuroendocrine cell line: implications for neuropeptide biosynthesis // J. Neurochim. - 1992. - 58. N 6. - P. 2011-2018.

230. Kluger M.J. Fever: vole of pyrogens and cryagens // Physiol. Rev. - 1991. - 71. - P. 93.

231. Krahl S.E., Berman R.F., Hannigan J.H. Electrophysiology of hippocampal Ca1 neurons after prenatal ethanol exposure // Alcohol - 1999. - 17, N 2. - P. 125-131.

232. Kuhn P.E., Miller M.W. Expression of p53 and Alz-50 immunoreactivity in rat cortex - effect of prenatal exposure to ethanol // Exp. Neurol. - 1998. - 154, N 2. - P. 418-429.

233. Kulkosky P.J., Allison C.T., Allison T.G., Marquez L.M., Mattson B.J. Interaction of CCK and 8-Oh-Dpat in the satiation of alcohol intake // Alcohol - 1998. - 16, N 4. - P. 305-309.

234. Kulkosky P. J., Allison C. T., Mattson B. J. Thyrotropin releasing hormone decreases alcohol intake and preference in rats. //Alcohol. - 2000. - 20, N 1. - P. 87-91.

235. Kulkosky P. J., Clayborne Y. J., Sandoval S. L. Cholecystokinin and bombesin inhibit ethanol and food intake in rats selectively bred for ethanol sensitivity. // Alcohol. Clin. Exp. Res. - 1993. - 17, N 3. - P. 545-551.

236. Lacourse K.A., Friishansen L., Rehfeld J.F., Samuelson L.C. Disturbed progastrin processing in carboxypeptidase E deficient fat mice // FEBS Lett. - 1997. - 416, N 1. - P. 45-50.

237. Laslop A., Tschernitz C. Effects of nerve growth factor on the biosynthesis of chromogranin A and B, secretogranin II and carboxy-peptidase H in rat PC12 cells // Neuroscience. -1992. - 49, N 2. - P. 443-450.

238. Li T.K. Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. // J. Stud. Alcohol. - 2000. - 61, N 1. - P. 5-12.

239. Li Y., McGivern R.F., Nagahara A.H., Handa R.J Alterations in the estrogen sensitivity of hypothalamic proenkephalin mRNA expression with age and prenatal exposure to alcohol // Molecular Brain Research - 1997. - 47, N 1-2. - P. 215-222.

240. Lingfordhughes A.R., Acton P.D., Gacinovic S., Boddington S.J.A., Costa D.C., Pilowsky L.S., Ell P.J., Marshall E.J., Kerwin R.W. Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women - preliminary findings from an I-123 lomazenil single- photon-emission-tomography study // Alcohol. Clin. Exp. Res. - 2000. - 24, N 9. - P. 1449-145.

241. Livy D.J., Maier S.E., West J.R. Fetal alcohol exposure and temporal vulnerability - effects of binge like alcohol exposure on the ventrolateral nucleus of the thalamus // Alcohol. Clin. Exp. Res. - 2001. - 25, N 5. - P. 774-780.

242. Loh Y.P., Brownstein M.J., Gainer H. Proteolysis in neuropeptide processing and ofker neurol functions // Ann.Rev.Neurosci. - 1984. - 7. - P. 183-185.

243. Loh Y.P., Snell C.R., Cool D.R. Receptor mediated targeting of hormones to secretory granules, role of carboxypeptidase E // Trends Endocrinol. Met. - 1997. - 8, N 4, P. 130-137.

244. Lowry O.H., Rosebrought N.J., Farr A.G., Randall R.J. Protein measurement with Folin phenol reagent // J. Biol. Chem. - 1951. - 193, N 1. - P. 265-275.

245. Luсas D., Penneс Y., Menez J. F., Floch H. H., Menn G. Le. Acetaldehyde adducts with serum proteins are not responsible for decreased drug binding in alcoholic patients. // Drug Alс. Depend. - 1986. - 17, N 1. - P. 67-71.

246. Lynch D.R., Braas K.M., Hutton J.C., Snyder S.H. Carboxypeptidase E (CPE) immunocytochemical localization in the rat central nervous system and pituitary gland // J. Neurosci. - 1990. - 10. - N 5. - P. 1592-1599.

247. Lynch D.R., Snyder S.M. Neuropeptides: multiple forms, metabolic pathnays and receptors // Ann. Rev. Biochem. - 1986. - 55. - P. 773-799.

248. Lynch D.R., Venable J.C., Snyder S.H. Enkephalin convertase in the heart: similar disposition to atrial natriuretic factor // Endocrinology. - 1988. - 122, N 6. - P. 2683-2691.

249. Lynch D.R., Venable J.C., Strittmatter S.M., Snyder S.H. Enkephalin convertase: charasterization and localization using [3H]guanidinoethyl-mercaptosuccinic acid // Biochimie. - 1988. - 70, N 1. - P. 57-64.

250. MacCumber M.W., Snyder S.H., Ross C.A. Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization // J. Neurosci. - 1990. - 10, N 8. - P. 2850-2860.

251. Mackin R.B., Noe B.D. Charasterization of an islet carboxypep-tidase B involved in prohormone processing // Endocrinology. - 1987. - 120, N 2. - P. 457-468.

252. Maier S.E., West J.R. Regional differences in cell loss associated with binge- like alcohol exposure during the first 2 trimesters equivalent in the rat // Alcohol - 2001. - 23, N 1. - P. 49-57.

253. Mains R.E., Eipper B.A. Secretion and regulation of two biosyntetic enzyme activities, peptidyl-glycine -amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells // Endocrinology. - 1984. - 115, N 5. - P. 1683-1690.

254. Maletti M., Besson J., Bataille D., Laburthe M., Rosselin M. Ontogenesis and immunoreactive forms of vasoactive intestinal peptide in rat brain // Acfa Endocrinol. - 1980. - 93, № 4. - P. 479-487.

255. Manser E., Fernandez D., Loo L., Goh P.Y., Monfries C., Hall C., Lim L. Human carboxypeptidase E., Isolation and characterization of the cDNA, sequ-ence conservation, expression and processing in vitro // Biochem. J. 1990. - 267, N 2. - P. 517-525.

256. Marks N., Berg N., Benuck M., Lo E.S., Novachenko H., Seyfried C. Prodynorphin processing by rat CNS fractions and purified enzyme: formation of dynorphin A 1-8 by sulfhydryl activated carboxypeptidase and peptidyl dipeptidase // Neurochem. Intern. - 1987. - 10, N 4. - P. 413-422.

257. Marks N., Grynbaum A., Benuck M. On the sequential cleavage of myelin basic protein by cathepsin A and D // J. Neurochem. - 1976. N 27. - P. 765-768.

258. Marks N., Stern F., Lajtha A. Changes in proteolytic enzymes and proteins during maturation of the brain // Brain Res. - 1975. - 86, № 2. - P. 307-322.

259. Martinez-Millan L., De Gandaries J.M., Irazusta J., Echevarria E., Casis L. Developmental changes of amino peptidase activity in the cortex of the cat hrain // Int. J. Dev. Neurosci. - 1993. - 11, № 1. - P. 11-15.

260. Mathieu-Kia A. M., Resson M. J. Repeatet administration of сoсaine, niсotine and ethanol: effeсts on preprodynorphin, preprotaсhykinin H and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat // Moleс. Brain Res. - 1998. - 54. - P. 141-151.

261. Matsas R., Kenny A.S., Turner A.J. An immunohistochemical study of endopeptidase 24.11 (enkephalinase) in the pig nervous system // Neuroscience. - 1986. - 18, № 4. - P. 991-996.

262. McDonald J.K., Schwabe C. Intracellular exopeptidase // Proteinases in mammalian cells and tissues / Barrett A.J. (ed.). Amsterdam: Elsevier/North Holland Biomedical Press - 1977. - P. 311-391.

263. McGivern R.F., Clancy A.N., Mousa S., Couri D., Noble E.P. Prenatal alcohol exposure alters enkephalin levels, without affecting ethanol preference // Life Sci. - 1984. - 34, N 6. - P. 585-589.

264. McGivern R.F., Ervin M.G., Mcgeary J., Somes C., Handa R.J. Prenatal ethanol exposure induces a sexually dimorphic effect on daily water-consumption in prepubertal and adult rats // Alcohol. Clin. Exp. Res. - 1998. - 22, N 4. - P. 868-875.

265. McGivern R.F., Handa R.J., Raum W.J. Ethanol exposure during the last week of gestation in the rat - inhibition of the prenatal testosterone surge in males without long-term alterations in sex behavior // Neurotoxicol. Teratol. - 1998. - 20, N 4. - P. 483-490.

266. McMillian M.K., Hudson P.M., Lec D.Y., Thai L., Hung G.H., Hong J.S. Developmental changes . in rat adrenal enkephalin premrsor: peptide ratio // Brain. Res. Dev. Brain. Res. - 1993. - 71, № 1. - P. 75-80.

267. Meunier J.-C. The opioid peptides and their receptors // Biochimie. - 1986. - 68. - P. 1153-1158.

268. Mihalick S.M., Crandall J.E., Langlois J.C., Krienke J.D., Dube W.V. Prenatal ethanol exposure, generalized learning impairment, and medial prefrontal cortical deficits in rats // Neurotoxicol. Teratol. - 2001. - 23, N 5. - P. 453-462.

269. Miller M.W. A longitudinal study of the effects of prenatal ethanol exposure on neuronal acquisition and death in the principal sensory nucleus of the trigeminal nerve - interaction with changes induced by transection of the infraorbital nerve // J Neurocytol - 1999. - 28, N 12. - P. 999-1015.

270. Mitra A., Song L.X., Fricker L.D. The C-terminal region of carboxypeptidase E is involved in membrane-binding and intracellular routing in AtT-20 cells // J. Biol. Chem. - 1994. - 269, N 31. - P. 19876-19881.

271. Moore D.B., Ruygrok A.C., Walker D.W., Heaton M.B. Effects of prenatal ethanol exposure on parvalbumin expressing GABAergic neurons in the adult rat medial septum // Alcohol. Clin. Exp. Res. - 1997. - 21, N 5. - P. 849-856.

272. Mourik J., Raeven P., Steur K., Addink A.D.F. Anatrobic metabolism of red skeletsl muscle of goldfish, Carassius auratus (L). Mitochondrial produced acetaldehyde as anaerobic electron acceptor // FEBS Lett. - 1982. - 137, N 1. Р. 111-114.

273. Naggert J.K., Fricker L.D., Varlamov O., Nishina P.M., Rouille Y., Steiner D.F., Carroll R.J., Paigen B.J., Leiter E.H. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity // Nature Genetics. - 1995. - 10, N 2. - P. 135-142.

274. Nalamachu S.R., Song L.X., Fricker L.D. Regulation of carboxypeptidase E - effect of Ca2+ on enzyme-activity and stability // J. Biol. Chem. - 1994. - 269, N 15. - P. 11192-11195.

275. Nemeskeri A., Acs Z., Toth B.E. Prolactin-synthesiring and prolactin-releasing activity of fetal andeurly postnatal rat piluitaries: in vivo and in vitro studies using RIA, reverse hemolytic plaque assay and immunocytochemistry. // Neuroendocrinology. - 1995. - 61. - P. 687-694.

276. Nolan C.J., Bestervelt L.L., Mousigian C.A., Maimansomsuk P., Cai Y., Piper W.N. Chronic ethanol consumption depresses hypothalamic-pituitary-adrenal function in aged rats // Life Sci. - 1991. - 49, N 25. P. 1923-1928.

277. Norenberg U., Richter D. Processing of the oxytocin precursor: isolation of an exopeptidase from neurosecretory granules of bovine pituitaries // Biochem. Biophys. Res. Commun. - 1988. - 156, N 2. - P. 898-904.

278. Oakes M. G., Davis T. P. The ontogeny of enzymes involved in post-translational processing and metabolism of neuropeptides. // Dev. Brain Res. - 1994. - 80. N 1-2. P. 127-136.

279. Orskov C., Buhl T., Rabenhoj L., Kofod H., Holst J. J. Carboxypeptidase-B-like processing of the C-terminus of glucagon-like peptide-2 in pig and human small intestine // FEBS Lett. - 1989. - 247, N 2. P. 193-196.

280. Osborn J.A., Kim C.K., Steiger J., Weinberg J. Prenatal ethanol exposure differentially alters behavior in males and females on the elevated plus-maze // Alcohol. Clin. Exp. Res. - 1998. - 22, N 3. - P. 685-696.

281. Osborn J.A., Yu C., Gabriel K., Weinberg J. Fetal ethanol effects on benzodiazepine sensitivity measured by behavior on the elevated plus-maze // Pharmacol. Biochem. Behav. - 1998. - 60, N 3. - P. 625-633.

282. Osborn J.A., Yu C., Stelzl G.E., Weinberg J. Effects of fetal ethanol exposure on pituitary-adrenalsSensitivity to secretagogues // Alcohol. Clin. Exp. Res. - 2000. - 24, N 7. - P. 1110-1119.

283. Oyarce A.M., Hand T.A., Mains R.E., Eipper B.A. Dopaminergic regulation of secretory granule associated proteins in rat intermediate pituitary // J. Neurochem. - 1996. - 67, N 1. - P. 229-241.

284. Ozer E., Sarioglu S., Gure A. Effects of prenatal ethanol exposure on neuronal migration, neuronogenesis and brain myelination in the mice brain // Clin. Neuropatol. - 2000. - 19, N 1. - P. 21-25.

285. Parkinson D. Carboxypeptidase H in bovine pituitary gland: soluble forms are not processed at the C-terminus // Mol. Cell. Endocrinol. - 1992. - 86, N 3. - P. 221-233.

286. Parkinson D. Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences // J. Biol. Chem. - 1990. - 265, N 28. - P. 17101-17105.

287. Perloff M.D., Kream RM., Beinfeld M.C. Reduced levels of substance P in the brains of Cpe(Fat)/Cpe(Fat) Mice // Peptides. - 1998. - 19, N 6, P. 1115-1117.

288. Prendergast M.A., Harris B.R., Blanchard J.A., Mayer S., Gibson D.A., Littleton J.M. In-vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat // Alcohol. Clin. Exp. Res. - 2000. - 24, N 12. - P. 1855-1861.

289. Pshezhetsky A.V., Potier M. Direct affinity purification and supramolecular organization of human lysosomal cathepsin A // Arch. Biochem. Biophys. - 1994. - 313, N 1. - P. 64-70.

290. Rasmussen D.D., Boldt B.M., Bryant C.A., Mitton D.R., Larsen S.A., Wilkinson C.W. Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis // Alcohol. Clin. Exp. Res. - 2000. - 24, N 12. - P. 1836-1849.

291. Revskoy S., Halasz I., Redei E. Corticotropin-releasing hormone and proopiomelanocortin gene expression Is altered selectively in the male rat fetal thymus by maternal alcohol consumption // Endocrinology - 1997. - 138, N 1. - P. 389-396.

292. Reznik S. E., Salafia C. M., Lage J. M., Fricker L. D. Immunohistochemical localization of carboxypeptidase-E and carboxypeptidase-D in the human placenta and umbilical-cord // J. Histochem.and Cytochem. - 1998. - 46, N 12. P. 1359-1367.

293. Rikke B.A., Simpson V.J., Montoliu L., Johnson T.E. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics // Alcohol. Clin. Exp. Res. - 2001. - 25, N 2. - P. 171-176.

294. Rintala J., Jaatinen P., Lu W., Sarviharju M., Eriksson C.J.P., Laippala P., Kiianmaa K., Hervonen A. Effects of lifelong ethanol consumption on erebellar layer volumes in AA and ANA rats // Alcohol. Clin. Exp. Res. - 1997. - 21, N 2. - P. 311-317.

295. Rivier C. Female rats release more corticosterone than males in response to alcohol: influence of circulating sex steroids and possible consequences for blood alcohol levels. // Alcohol. Clin. Exp. Res. - 1993. - 17. N. 4. - P. 854-859.

296. Rivier C., Bruhn T., Vale W. Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF) // J. Pharmacol. Exp. Ther. - 1984. - 229, N 1. - P. 127-131.

297. Rivier C., Imaki T., Vale W. Prolonged exposure to alсohol: effeсt on сRF mRNA levels, and CRF - and stress-induсed ACTH seсretion in the rat // Brain Res. - 1990. - 520, N 1-2. - P. 1-5.

298. Rivier C., Rivest S., Vale W. Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms // Alcohol. Clin. Exp. Res. - 1992. - 16, N 5. - P. 935-941.

299. Rockman C.E., Markert L.E., Delrizzo M. Effects of prenatal ethanol exposure on ethanol-induced locomotor activity in rat // Alcohol. - 1989. - 6, N 5. - P. 353-356.

300. Rodriguez C., Brayton K.A., Brownstein M., Dixon J.E. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin releasing factor // J. Biol. Chem. - 1989. - 264, N 10. - P. 5988-5995.

301. Rossier, J., Barres, E., Hutton, J.C., Ricknell, R.J. Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes // Anal. Biochem. - 1989. - 178, N 1. - P. 27-31.

302. Rouille Y., Chauvet J., Acher R. Partial conversion of vasopressinyl-Gly-Lys-Arg into pharmacologically active vasopressin through secretory granule carboxypeptidase E and alpha-amidating processing enzymes // Biochem. Int. - 1992. - 26, N 4. - P.739-746.

303. Rovere C., Viale A., Nahon J., Kitabgi P. Impaired processing of brain proneurotensin and promelanin concentrating hormone in obese fat/fat mice // Endocrinology. - 1996. - 137, N 7. - P. 2954-2958.

304. Roy A., Mittal N., Zhang H., Pandey S. C. Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA dinding in rat brain during alcohol drinking and withdrawal // J. Pharmacol. Exp. Ther. - 2002. - 301, N 2, - P. 774-784. ХЭ364

305. Salonen I., Huhtaniemi I. Effects of chronic ethanol diet on pituitary-testicular function of the rat // Biol. Reprod. -1990. - 42. P. 55-62.

306. Sarviharju M., Jaatinen P., Hyytia P., Hervonen A., Kiianmaa K. Effects of lifelong ethanol consumption on drinking behavior and motor impairment of alcohol-preferring AA and alcohol-avoiding ANA rats // Alcohol - 2001. - 23, N 3. - P. 157-166.

307. Scarceriaux V., Pelaprat D., Lhiaubet A.M., Schimptf R.M., Tramu G., Rostene W. Developmental pattern of neurofensin content in rat hypothalamic neurons culbured in serum free medium-comparison with in vivo data // Dev. Brain Res. - 1994. - 81, № 1. - P. 128-130.

308. Schlamp C.L., Nickells R.W. Light and dark cause a shift in the spatial expression of a neuropeptide processing enzyme in the rat retina // J. Neurosci. - 1996. - 16, N 7. - P. 2164-2171.

309. Schneider M.L., Moore C.F., Kraemer G.W. Moderate alcohol during pregnancy - learning and behavior in adolescent Rhesus-Monkeys // Alcohol. Clin. Exp. Res. - 2001. - 25, N 9. - P. 1383-1392.

310. Seizinger B.R., Brinn C., Herr A. Evidence for a differential postnatal development of proenkephalin B (prodynorphin) - derived opieid peptides in the rat hypothalamus // Endocrinology. - 1984. - 115, № 3. - P. 926-935.

311. Shen F.S., Loh Y.P. Intracellular Misrouting and Abnormal Secretion of Adrenocorticotropin and Growth Hormone in Cpe (Fat) Mice Associated with a Carboxypeptidase E Mutation // Proc. Nat. Acad. Sci. USA. - 1997. - 94, N 10. - P. 5314-5319.

312. Silva W.I., Benitez K., Ocasio J., Martinez L., Rosario N. Neuropeptide like immunoreactivities and carboxypeptide H activity associated with bovine brain clathrin coated vesicles // Neuropeptides. -1995. - 28, N 6, P. 341-349.

313. Sinha P., Halasz I., Choi J.F., Mcgivern R.F., Redei E. Maternal adrenalectomy eliminates a surge of plasma dehydroepiandrosterone in the mother and attenuates the prenatal testosterone surge in the male fetus // Endocrinology - 1997. - 138, N 11. - P. 4792-4797.

314. Skutohness C.D., Holroyde C.P., Nyers R.N. et al. Acetat in normal human blood // J. Clin. Invest. - 1979. - 64. - P. 708-713.

315. Sluyter F., Hof M., Ellenbroek B.A., Degen S.B., Cools A.R. Genetic, sex, and early environmental-effects on the voluntary alcohol - intake in Wistar rats // Pharmacol. Biochem. Behav. - 2000. - 67, N 4. - P. 801-808.

316. Smith D.R., Pallen C.J., Murphy D., Lim L. Pituitary-specific transcriptional initiation sites of the rat carboxypeptidase-H gene and the influence of thyroid hormone status // Mol. Endocrinol. - 1992. - 6, N 5. - P. 713-722.

317. Smyth D.G., Maruthainar K., Darby N.J., Fricker L.D. Catalysis of slow C terminal processing reactions by carboxypeptidase H // J. Neurochem. - 1989. - 53, N 2. - P. 489-493.

318. Song L.X, Fricker L.D. Calcium and pH dependent aggregation of carboxypeptidase E // J. Biol. Chem. - 1995. - 270, N 14. - P. 7963-7967.

319. Song L.X., Fricker L.D. The pro region is not required for the expression or intracellular routeing of carboxypeptidase E // Biochemical Journal. - 1997. - 323, N 4. - P. 265-271.

320. Spencer R.L., McEwen B.S. Impaired adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress in aged rats // Neuroendocrinol. - 1997. - 65, N 5. - P. 353-359.

321. Spenсer R. L., MсEwen B. S. Adaptation of the hypothalamiс- pituitary-adrenal axis to сhroniс ethanol stress. // Neuroendoсrinology. - 1990. - 52, N 5. - P. 481-489.

322. Srivastava V.K., Hiney J.K., Dearth R.K., Les Dees W. Chronic effects of prepubertal ethanol administration on steroidogenic acute regulatory protein in the rat ovary.// Alcohol. Clin. Exp. Res. - 2002. - 26, N 1. - P. 107-113.

323. Stack G., Fricker L.D., Snyder S.H. A sensitive radiometric assay for enkephalin convertase and for carboxypeptidase B-like enzymes // Life Sci. - 1984. - 34. - P. 113-121.

324. Stege T. E. Induсtion of aсetaldehyde lipid peroxidation in hepatiс сell. // Reс. Commun. Chem. Phatal. Pharmaсol. - 1982. - 36, N 2. - P. 287-297.

325. Stone T.E., Li J.P., Bernasconi P. Purification and Characterization of the Manduca Sexta Neuropeptide Processing Enzyme Carboxypeptidase E // Arch. Insect Biochem. Phisiol. - 1994. - 27, N 3, P. 193-203.

326. Strittmatter S.M., Lynch D.R., Skyder S.H. Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin converting enzyme // Dev. Brain. Res. - 1986. - 29, № 2. - P. 207-215.

327. Strittmatter S.M., Lynch D.R., Snyder S.H. (3H)guanidinoethyl-mercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase // J. Biol. Chem. - 1984. - 259, N 19. - P. 11812-11817.

328. Sullivan K.A., Traurig H.H., Papka R.E. Ontogeny of neurotransmitter system in the paracervical ganglion and uterine cervix of the rat // Anat. Rec. - 1994. - 240, № 3. - P. 377-386.

329. Summers M. L., Gidley M. S., Sanders S. K. Aсetaldehydeenkephalins: eluсidation of the struсture of the aсetaldehyde adduсts of methionine-enkephalin and leuсine- enkephalin. // FEBS. - 1980. - 111, N 2. - P. 307-310.

330. Supattapone S., Fricker L.D., Snyder S.H. Purification and characterization of a membrane-bound enkephalin-forming carboxypeptidase, “enkephalin convertase” // Neurochem. - 1984. - 42, N 4. - P. 1017-1023.

331. Szot P., White S.S., Veith R.C., Rasmussen D.D. Reduced gene expression for dopamine biosynthesis and transport in midbrain neurons of adult male rats exposed prenatally to ethanol // Alcohol. Clin. Exp. Res. - 1999. - 23, N 10. - P. 1643-1649.

332. Tabakoff B., Hoffman P. L., Litjequist S. Effeсts of ethanol on the aсtivity of brain enzymes. // Enzyme. - 1987. - 37, N 1-2. - P. 70-86.


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