Активность основных карбоксипептидаз при действии нейролептиков
Рассмотрение острого введения диазепама и галоперидола на активность карбоксипептидазы Н, фенилметилсульфонилфторид-ингибируемой карбоксипептидазы и карбоксипептидазы М в головном мозге, надпочечниках и семенниках крыс через различные промежутки времени.
Рубрика | Биология и естествознание |
Вид | диссертация |
Язык | русский |
Дата добавления | 15.12.2008 |
Размер файла | 647,7 K |
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131. Ferrarese C., Mennini T., Pecora N., Pierpaoli C., Frigo M., Marzorati C., Gobbi M., Bizzi A., Codegoni A., Garattini S., Frattola L. Diazepam binding inhibitor (DBI) increases after acute stress in rat // Neuropharmacology. - 1991. - № 30. - Р. 1445-1452.
132. Ferrarese C., Vaccarino F., Alho H., Mellstrom B., Costa E., Guidotti A. Subcellular location and neuronal release of diazepam binding inhibitor // J. Neurochem. - 1987. - V. 48, № 4. - Р. 1093-1102.
133. Ferrero P., Costa E., Conti-Tronconi B., Guidotti A. A diazepam binding inhibitor (DBI)-like neuropeptide is detected in human brain // Brain. Res. - 1986. - V. 399, № 1. - Р. 136-142.
134. Fiedorek F.T., Parkinson D. Carboxypeptidase H processing and secretion in rat clonal beta-cell lines // Endocrinology. - 1992. -V. 131, № 3. - P. 1054-1062.
135. Fox C.A., Mansour A., Watson S.J. The effects of haloperidol on dopamine receptor gene expression // Jr. Exp. Neurol. - 1994. - V. 130, № 2. - Р. 288-303.
136. Fricker L.D. Activation and membrane binding of carboxypeptidase E // J. Cell. Biochem. - 1988. - № 38. - P. 279-289.
137. Fricker L.D. Carboxypeptidase E // Ann. Rev. Physiol. - 1988. - № 50. - P. 309-321.
138. Fricker L.D., Adelman J.P., Douglass J., Thompson R.C., Strandmann R.P., Hutton J. Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme // Mol. Endocrinol. - 1989. - V. 3, № 4. - P. 666-673.
139. Fricker L.D., Berman Y.L., Leiter E.H., Devi L.A. Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing // J. Biol. Chem. - 1996. - V. 271, № 48. - Р. 30619-30624.
140. Fricker L.D., Das B., Angeletti R.H. Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10) // J. Biol. Chem. - 1990. - V. 265, № 5. - P. 2476-2482.
141. Fricker L.D., Das B., Klein R.S., Greene D., Jung Y.K. Regulation of carboxypeptidase E (enkephalin convertase) // NIDA Res. Monogr. - 1991. - № 111. - P. 171-187.
142. Fricker L.D., Devi L. Comparison of a spectrophotometric, a fluorometric, and a novel radiometric assay for carboxypeptidase E (EC 3.4.17.10) and other carboxypeptidase B-like enzymes // Anal. Biochem. - 1990. - V. 184, № 1. - Р. 21-27.
143. Fricker L.D., Herwert E. Comparision of a carboxypeptidase E-like enzyme in human, mouse, Xenopus, shark and Aplysia neural tissue // Brain Res. - 1988. - V. 453, № 1-2. - P. 281-286.
144. Fricker L.D., Plummer T.H.Jr., Snyder S.H. Enkephalin convertase: potent, selective and irreversible inhibitors // Biochem. Biophys. Res. Commun. - 1983. - V. 11, № 3. - P. 994-1000.
145. Fricker L.D., Reaves B.J., Das B., Dannies P.S. Comparison of the regulation of carboxypeptidase E and prolactin in GH4C1 cells, a rat pituitary cell line // Neuroendocrinology. - 1990. - V. 51, № 6. - P. 658-663.
146. Fricker L.D., Rigual R.J., Diliberto E.J.Jr., Viveros O.H. Reflex splanchnic nerve stimulation increases levels of carboxypeptidase E mRNA and enzy-matic activity in the rat adrenal medulla // J. Neurochem. - 1990. - V. 55, N 2. - P. 461-467.
147. Fricker L.D., Snyder S.H. Enkephalin convertase: purification and charasterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenall chromaffin granules // Proc. Natl. Acad. Sci. USA. - 1982. - № 79. - P. 3886-3890.
148. Fricker L.D., Snyder S.H. Purification and characterization of enkephalin convertase, an enkephaline-synthesizing carboxypeptidase // J. Biol. Chem. - 1983. - V. 258, № 18. - P. 10950-10955.
149. Fricker L.D., Supattapone S., Snyder S.H. Enkephalin convertase: a specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain and pituitary gland // Life Sci. - 1982. - № 31. - P. 1841- 1844.
150. Gandolfo P., Patte C., Thoumas J.L., Leprince J., Vaudry H., Tonon M.C. The endozepine ODN stimulates [3H]thymidine incorporation in cultured rat astrocytes // Neuropharmacology. - 1999. - V. 38, № 5. - Р. 725-732.
151. Garcia de Yebenes E., Li S., Pelletier G. Regulation of proopiomelanocortin gene expression by endogenous ligands of the GABAA receptor complex as evaluated by in situ hybridization in the rat pars intermedia // Brain. Res. - 1997. - V. 750, № 1-2. - Р. 277-284.
152. Gavish M., Bachman I., Shoukrun R., Katz Y., Veenman L., Weisinger G., Weizman A. Enigma of the Peripheral Benzodiazepine Receptor // PHARMACOLOGICAL REVIEWS. - 1999. - V. 51, № 4. - Р. 629-650.
153. George S.R., Kertesz M. Dopamine receptors regulate Met-enkephalin content in pituitary // Brain. Res. - 1985. - V. 334, № 1. - Р. 187-189.
154. George S.R., Kertesz M. Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission // Peptides. - 1987. - V. 8, № 3. - Р. 487-492.
155. Givalois L., Grinevich V., Li S., Garcia-De-Yebenes E., Pelletier G. The octadecaneuropeptide-induced response of corticotropin-releasing hormone messenger RNA levels is mediated by GABA(A) receptors and modulated by endogenous steroids // Neuroscience. - 1998. - V. 85, № 2. - Р. 557-567.
156. Givalois L., Li S., Pelletier G. Differential involvement of adrenal and gonadal steroids in anterior and intermediate pituitary pro-opiomelanocortin mRNA expression induced by the endogenous benzodiazepine, octadecaneuropeptide, in adult male rats // J. Endocrinol. - 1999. - V. 161, № 2. - Р. 307-316.
157. Gregg D., Goedken E., Gaikin M., Wendell D., Gorski J. Decreased expression of carboxypeptidase E protein is correlated to estrogen-induction of rat pituitary tumors // Mol. Cell. Endocrinol. - 1996. - V. 117, N 2. - P. 219-225.
158. Grigoriants O., Devi L., Fricker L.D. Dopamine antagonist haloperidol increases carboxypeptidase E mRNA in rat neurointermediate pituitary but not in various other rat tissues. // Molecular brain research. - 1993. - V. 19, № 1-2. - Р. 161-164.
159. Guest P.C., Arden S.D., Rutherford N.G., Hutton J.C. The posttranslational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans // Mol. Cell. Endocrinol. - 1995. - 113, № 1, P. 99-108.
160. Guest P.C., Ravazzola M., Davidson H.W., Orci L., Hutton J.C. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans // Endocrinology. - 1991. - V. 129, № 2. - P. 734-740.
161. Guest P.C., Rhodes C.J., Hutton J.C. Regulation of the biosynthesis of insulin secretory granule proteins. Coordinate translational control is exerted on some, but not all, granule К. matrix constituents // Biochem. J. - 1989. - 257, № 2. - P. 431-437.
162. Guimaraes V.M., Zuardi A.W., Del Bel E.A., Guimaraes F.S. Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum // Life Sci. - 2004. - V. 75, № 5. - Р. 633-638.
163. Haefely W.E. Central action of benzodiazepines: general introduction // British Journal of Psychiatry. - 1978. - № 133. - Р. 231-238.
164. Hagino Y., Okuwa M., Moroji T. Effects of ceruletide and haloperidol on the hypothalamo-pituitary beta-endorphin system and brain beta-endorphin contents in the rat: with special reference to effects of ceruletide in chronically haloperidol-treated rats // Neuropeptides. - 1991. - V. 18, № 1. - Р. 1-14.
165. Ham J., Smyth D.G. Beta-endorphin processing in pituitary and brain is sensitive to haloperidol stimulation // Neuropeptides. - 1985. - V. 5, № 4-6. - Р. 497-500.
166. Harmar A. J. Neuropeptides // Transm. Mol. In the brain. - 1987. - N 2. - P. 17-26.
167. Heimer L., Alheid G.F., Zaborsky L. Basal ganglia / Paxinos G, ed // The rat nervous system, V. 1, Forebrain and midbrain. - New York, 1985. - Р. 37-86.
168. Herman Z.S., Huzarska M., Kmieciak-Kolada K., Kowalski J. Chronic treatment with chlorpromazine, thioridazine or haloperidol increases striatal enkephalins and their release from rat brain // Psychopharmacology (Berl). - 1991. - V. 104, № 1. - Р. 106-112.
169. Herpfer I, Lieb K. Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders // World J. Biol. Psychiatry. - 2003. - V. 4, № 2. - P. 56-63.
170. Holloway C.D., Kenyon C.J., Dowie L.J., Corrie J.E., Gray C.E., Fraser R. Effect of the benzodiazepines diazepam, des-N-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro: Location of site of action // J. Steroid. Biochem. - 1989. - № 33. - Р. 219-225.
171. Hollt V., Bergmann M. Effects of acute and chronic haloperidol treatment on the concentrations of immunoreactive beta-endorphin in plasma, pituitary and brain of rats // Neuropharmacology. - 1982. - V. 21, № 2. - Р. 147-154.
172. Hollt V., Haarmann I., Seizinger B.R., Herz A. Chronic haloperidol treatment increases the level of in vitro translatable messenger ribonucleic acid coding for the beta-endorphin/adrenocorticotropin precursor proopiomelanocortin in the pars intermedia of the rat pituitary // Endocrinology. - 1982. - V. 110, № 6. - Р. 1885-1891.
173. Holmes A., Heilig M., Rupniak N.M., Steckler T., Griebel G. Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders // Trends. Pharmacol. Sci. - 2003. - V. 24, № 11. - Р. 580-588.
174. Holsboer F. The role of peptides in treatment of psychiatric disorders // J. Neural. Transm. Suppl. - 2003. - V. 64. - P. 17-34.
175. Hook V.Y.H. Carboxypeptidase B-like activity for the processing of enkephalin precursors in the membrane component of bovine adreno-medullary chromaffin granules // Neuropeptides. - 1984. - V. 4, № 2. - P. 117-126.
176. Hook V.Y.H., Affolter H.U. Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones // FEBS Lett. - 1988. -V. 238, № 2. - P. 338-342.
177. Hook V.Y.H., Affolter H.U., Palkovits M. Carboxypeptidase H in the hypothalamo-neurohypophysal system: evidence for processing of a prohormone-processing enzyme during axonal transport // J. Neurosci. - 1990. - V. 10, № 10. - P. 3219-3226.
178. Hook V.Y.H., Eiden L.E. (Met)-enkephalin and carboxypeptidase processing enzyme are co-released from chromaffin cells by cholinergic stimulation // Biochem. Biophys. Res. Commun. - 1985. - № 128. - P. 563-570.
179. Hook V.Y.H., Eiden L.E. Two peptidases that convert 125J-Lys-Arg-(Met)-enkephalin and 125J-enkephalin-Arg6, respectively, to 125J-(Met)-enkephalin in bovine adrenal medullary chromaffin granules // FEBS Lett - 1984. - V. 172, № 2. - P. 212-218.
180. Hook V.Y.H., LaGamma E.F. Product inhibit of carboxypeptidase H // J. Biol. Chem. - 1987. - V. 262, № 26. - P. 12583-12588.
181. Hook V.Y.H., Loh Y.P. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary // Proc. Natl. Acad. Sci. USA. - 1984. - N 81. - P. 2776-2780.
182. Hooper N.M. Angiotensin converting enzyme: implications from molecular biology for its physiological functions // Int. J. Biochem. - 1991. - V. 23, № 7-8. - P. 641-647.
183. Houdi A.A., Van Loon G.R. Haloperidol-induced increase in striatal concentration of the tripeptide, Tyr-Gly-Gly, provides an index of increased enkephalin release in vivo // J. Neurochem. - 1990. - V. 54, № 4. - Р. 1360-1366.
184. Hsueh W.A. Proteases in hormon production and metabolism // Int. Symp. “Proteases: Potent Role in Health and Disease” (Wursburg, 1982): Proc. - New York, London, 1984. - P. 141-151
185. Inoue A., Seto M., Sugita S., Hide I., Hirose T., Koga N., Kikuchi T., Nakata Y. Differential effects on D2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary // Brain. Res. Mol. Brain. Res. - 1998. - V. 55, № 2. - Р. 285-292.
186. Irminger J.C., Verchere C.B., Halban P.A. Carboxypeptidase E is not a sorting receptor for proinsulin // Mol. Biol. Cell. - 1997. - № 8. - P. 1786-1786.
187. Jaber M., Tison F., Fournier M., Bloch B. Differential influence of haloperidol and sulpiride on dopamine-receptors and peptide messenger-RNA levels in the rat striatum and pituitary // Brain. Res. Mol. Brain Res. - 1994. - V. 23, № 1-2. - P. 14-20.
188. Jacobi J.M., Lloyd H.M., Meares J.D. Nuclear diameter in the anterior pituitary gland of the rat: effects of estrogen, bromocriptine, and haloperidol // J. Histochem. Cytochem. - 1982. - V. 30, № 7. - Р. 677-681.
189. Johansson G.B., Skidgel R.A. Carboxypeptidase M (cpm) converts epidermal growthfactor (EGF) to Des-Arg53-EGF // FASEB J. - 1994. - V. 8, № 5. - P. 930-935.
190. Jung Y.K., Kunczt C.J., Pearson R.K., Dixon J.E., Fricker L.D. Structural characterization of the rat carboxypeptidase-E gene // Mol. Endocrinol. - 1991. - V. 5, № 9. - Р. 1257-1268.
191. Jung Y.K., Kunczt C.J., Pearson R.K., Fricker L.D., Dixon J.E. Expression of the rat carboxypeptidase-E gene in neuroendocrine and nonneuroendocrine cell lines // Mol. Endocrinol. - 1992. - V. 6, № 12. - P. 2027-2037.
192. Katsura M., Mohri Y., Shuto K., Tsujimura A., Ukai M., Ohkuma S. Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains // Brain. Res. Mol. Brain. Res. - 2002. - V. 104, № 1. - Р. 103-109.
193. Khalil R.H., Soliman M.R. Diazepam alters caffeine-induced effects on beta-endorphin levels in specific rat brain regions // Life Sci. - 1997. - V. 61, № 25. - Р. 2485-2490.
194. Khan R.M., Soliman M.R. Effects of benzodiazepine agonist, antagonist and inverse agonist on ethanol-induced changes in beta-endorphin levels in specific rat brain regions // Pharmacology. - 1993. - V. 47, № 6. - Р. 337-343.
195. Kilpatrick D.L., Howells R.D., Noe M., Bailey L.C., Udenfriend S. Expression of preproenkephalin-like mRNA and its peptide products in mammalian testis and ovary // Proc. Natl. Acad. Sci. USA. - 1985. - V. 82, № 21. - Р. 7467-7469.
196. Khanna A.S., Waisman D.M. Metabolism and intracellular proces¬sing of pro-tein hormones // Hormon. Act. - 1988. - N 1. - P. 117-132.
197. Klein R.S., Das B., Fricker L.D. Secretion of carboxypeptidase E from cultured astrocytes and from AtT-20 cells, a neuroendocrine cell line: implications for neuropeptide biosynthesis // J. Neurochem. - 1992 - V. 58, № 6. - P. 2011-2018.
198. Klein R.S., Fricker L.D. Heterogeneous expression of carboxypeptidase E and proenkephalin mRNAs by cultured astrocytes // Brain. Res. - 1992. - V. 569, № 2. - Р. 300-310.
199. Konkoy C.S., Oakes M.G., Davis T.P. Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions // Peptides. - 1993. - V. 14, № 5. - Р. 1017-1020.
200. Konkoy C.S., Waters S.M., Davis T.P. Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex // Eur. J. Pharmacol. - 1996. - V. 297, № 1-2. - Р. 47-51.
201. Krieger D.T. Brain peptides: what, where, and why? // Science. - 1983. - V. 222, № 4627. - P. 971-985.
202. Krueger K.E., Papadopoulos V. Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells // J. Biol. Chem. - 1990. - № 265. - Р. 15015-15022.
203. Lacourse K.A., Friis-Hansen L., Samuelson L.C., Rehfeld J.F. Altered processing of procholecystokinin in carboxypeptidase E-deficient fat mice: differential synthesis in neurons and endocrine cells // FEBS Lett. - 1998. - V. 436, № 1. - Р. 61-66.
204. Laslop A., Tschernitz C. Effects of nerve growth factor on the biosynthesis of chromogranin A and B, secretogranin II and carboxy-peptidase H in rat PC12 cells // Neuroscience. - 1992. - V. 49, N 2. - P. 443-450.
205. Law A.J., Hutchinson L.J., Burnet P.W., Harrison P.J. Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex. // J. Neurosci. Res. - 2004. - V. 76, № 3. - Р. 376-382.
206. Leprince J., Oulyadi H., Vaudry D., Masmoudi O., Gandolfo P., Patte C., Costentin J., Fauchere J.L., Davoust D., Vaudry H., Tonon M.C. Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN. Design of a potent endozepine antagonist // Eur. J. Biochem. - 2001. - V. 268, № 23. - Р. 6045-6057.
207. Li S., Givalois L., Pelletier G. Involvement of neurosteroids in the effect of the endogenous benzodiazepine receptor ligand octadecaneuropeptide (ODN) on gonadotropin-releasing hormone gene expression in rat brain // J. Neuroendocrinol. - 1997. - V. 9, № 3. - Р. 229-233.
208. Li S., Pelletier G. Dopamine regulation of gonadotropin-releasing hormone (GnRH) gene expression in the female rat brain // Neurosci. Lett. - 1992. - V. 146, № 2. - Р. 207-210.
209. Lihrmann I., Plaquevent J.C., Tostivint H., Raijmakers R., Tonon M.C., Conlon J.M., Vaudry H. Frog Diazepam-Binding Inhibitor - Peptide Sequence, cDNA Cloning, and Expression in the Brain // Proceedings of the national academy of sciences of the USA. - 1994. - V. 91, № 15. - Р. 6899-6903.
210. Lindefors N. Amphetamine and haloperidol modulate preprotachykinin A mRNA expression in rat nucleus accumbens and caudate-putamen // Brain. Res. Mol. Brain. Res. - 1992. - V. 13, № 1-2. Р. 151-154.
211. Llorens-Cortes C., Zini S., Gros C., Schwartz J.C. Dopaminergic regulation of enkephalin release // J. Neurochem. - 1991. - V. 56, № 4. - Р 1368-1375.
212. Loeffler J.P., Demeneix B.A., Kley N.A., Hollt V. Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the beta-adrenergic receptors and the adenylate cyclase system // Neuroendocrinology. - 1988. - V. 47, № 2. - Р. 95-101.
213. Loeffler J.P., Demeneix B.A., Pittius C.W., Kley N., Haegele K.D., Hollt V. GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary // Peptides. - 1986. - V. 7, № 2. - Р. 253-258.
214. Loeffler J.P., Kley N., Pittius C.W., Almeida O.F., Hollt V. In vivo and in vitro studies of GABAergic inhibition of prolactin biosynthesis // Neuroendocrinology. - 1986. - V. 43, № 4. - Р. 504-510.
215. Loh Y.P., Birch N.P., Castro M.G. Pro-opiomelanocortin and pro-vasopressin converting enzyme in pituitary secretory vesicles // Biochimie. - 1988 . - V. 70, № 1. - P. 11-16.
216. Loh Y.P., Snell C.R., Cool D.R. Receptor mediated targeting of hormones to secretory granules, role of carboxypeptidase E // Trends Endocrinol. Met. - 1997. - V. 8, № 4. P. 130-137.
217. Lowry O.H., Rosebrought N.J., Farr A.G., Randall R.J. Protein measurement with Folin phenol reagent // J. Biol. Chem. - 1951. - V. 193, № 1. - P. 265-275.
218. Luddens H., Korpi E.R. Biological function of GABAA/benzodiazepine receptor heterogeneity // J. Psychiatr. Res. - 1995. - V. 29, № 2. - P. 77-79.
219. Lynch D.R., Braas K.M., Hutton J.C., Snyder S.H. Carboxypeptidase E (CPE) immunocytochemical localization in the rat central nervous system and pituitary gland // J. Neurosci. - 1990. - V. 10, № 5. - P. 1592-1599.
220. Lynch D.R., Venable J.C., Snyder S.H. Enkephalin convertase in the heart: similar disposition to atrial natriuretic factor // Endocrinology. - 1990. - V. 122, № 6. - P. 2683-2691.
221. MacCumber M.W., Snyder S.H., Ross C.A. Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization // J. Neurosci. - 1990. - V. 10, № 8. - P. 2850-2860.
222. Maddalena D.J., Johnston G.A. Prediction of receptor peoperties and binding affinity of ligands to benzodiazepine-GABAA receptors using artiticial neural networks // J. Med. Chem. - 1995. - V. 38, № 4. - P. 715-724.
223. Mains R.E., Eipper B.A. Secretion and regulation of two biosyntetic enzyme activities, peptidyl-glycine -amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells // Endocrinology. - 1984. - V. 115, N 5. - P. 1683-1690.
224. Mannisto P.T., Laakso M.L., Jarvinen A., Rago L. Effects of Central and Peripheral Type Benzodiazepine Ligands on Growth-Hormone and Gonadotropin-Secretion in Male-Rats // Pharmacology s toxicology. - 1992. - V. 71, № 1. - Р. 75-80.
225. Manser E., Fernandez D., Loo L., Goh P.Y., Monfries C., Hall C., Lim L. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro // Biochem. J. - 1990. - V. 267, № 2. - P. 517-525.
226. Marcus M.M., Nomikos G.G., Malmerfelt A., Zachrisson O., Lindefors N., Svensson T.H. Effect of chronic antipsychotic drug treatment on preprosomatostatin and preprotachykinin A mRNA levels in the medial prefrontal cortex, the nucleus accumbens and the caudate putamen of the rat // Brain. Res. Mol. Brain. Res. - 1997. - V. 45, № 2. - Р. 275-282.
227. Marksteiner J., Saria A., Miller C.H., Krause J.E. Differential increases of neurokinin B- and enkephalin-like immunoreactivities and their mRNAs after chronic haloperidol treatment in the rat // Neurosci Lett. - 1992. - V. 148, № 1-2. - Р. 55-59.
228. Matsumoto Y., Okamura H., Ichitani Y., Yanaihara N., Nakajima T., Ibata Y. Immunocytochemical Survey of Haloperidol-Induced Immunoreactive Changes of (Met)Enkephalin-Arg6-Gly7-Leu8 in the Rat Forebrain // Brain research bulletin. - 1992. - V. 28, № 5. - Р. 683-695.
229. Meador-Woodruff J.H., Pellerito B., Bronstein D., Lin H.L., Ling N., Akil H. Differential effects of haloperidol on the rat pituitary: decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin // Neuroendocrinology. - 1990. - V. 51, № 3. - Р. 294-303.
230. Merchant K.M. c-fos antisense oligonucleotide specifically attenuates haloperidol-induced increases in neurotensin/neuromedin N mRNA expression in rat dorsal striatum // Mol. Cell. Neurosci. - 1994. - V. 5, № 4. - Р. 336-344.
231. Merchant K.M., Dobner P.R., Dorsa D.M. Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum // J. Neurosci. - 1992. - V. 12, № 2. - Р. 652-663.
232. Merchant K.M., Miller M.A. Coexpression of neurotensin and c-fos mRNAs in rat neostriatal neurons following acute haloperidol // Brain. Res. Mol. Brain. Res. - 1994. - V. 23, № 3. - Р. 271-277.
233. Merchant K.M., Miller M.A., Ashleigh E.A., Dorsa D.M. Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain // Brain. Res. - 1991. - V. 540, № 1-2. - Р. 311-314.
234. Mijnster M.J., Schotte A., Docter G.J., Voorn P. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat // Synapse. - 1998. - V. 28, № 4. - Р. 302-312.
235. Mikkelsen J.D. The KCNQ channel activator retigabine blocks haloperidol-induced c-Fos expression in the striatum of the rat // Neurosci. Lett. - 2004. - V. 362, № 3. - Р. 240-243.
236. Millington W.R., O'Donohue T.L., Mueller G.P. Dopaminergic agents selectively alter the post-translational processing of beta-endorphin in the intermediate pituitary of the rat // J. Pharmacol. Exp. Ther. - 1987. - V. 243, № 1. - Р. 160-170.
237. Mitchell V., Beauvillain J.C., Mazzuca M. GABAergic afferents modulate proenkephalin mRNA expression in the guinea pig hypothalamic magnocellular dorsal nucleus // Neurosci. Lett. - 1992. - V. 144, № 1-2. - Р. 189-194.
238. Morl F., Groschel M., Leemhuis J., Meyer D.K. Intrinsic GABA neurons inhibit proenkephalin gene expression in slice cultures of rat neostriatum // Eur. J. Neurosci. - 2002. - V. 15, № 7. - Р. 1115-1124.
239. Morris B., Hollt V., Herz A. Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists // Neuroscience. - 1988. - № 25. - Р. 525-532.
240. Morton D.B. The occurrence and function of proteolytic enzymes in the reproductive tract of mammals // Proteinases in Mammalian Cells and Tissue/Barrett A.J. (ed.). - Amsterdam: Elsevier/North Holland Biomedical Press, 1977. - P. 445-500.
241. Nagae A., Deddish P.A., Becker R.P., Anderson C.H., Abe M., Tan F., Skidgel R.A., Erdos E.G. Carboxypeptidase M in brain and peripheral nerves // J. Neurochem. - 1992. - V. 59, № 6. - P. 2201-2212.
242. Nalamachu S.R., Song L.X., Fricker L.D. Regulation of carboxypeptidase E - effect of Ca2+ on enzyme-activity and stability // J. Biol. Chem. - 1994. - 269, № 15. - P. 11192-11195.
243. Nemeroff C.B. Neurotensin: perchance an endogenous neuroleptic? // Biol. Psychiatry. - 1980. - V. 15. - Р. 283-302.
244. Nemeroff C.B., Kilts C.D., Levant B., Bissette G. Campbell-A Baldessarini-RJ Effects of the Isomers of N-Normal-Propylnorapomorphine and Haloperidol on Regional Concentrations of Neurotensin in Rat-Brain // Neuropsychopharmacology. - 1991. - V. 4, № 1. - Р. 27-33.
245. Nickells R.W., Schlamp C.L., Newton A.C., Williams D.S. Gene expression of the neuropeptide-processing enzyme carboxypeptidase E in rat photoreceptor cells // J. Neurochem. - 1993. - V. 61, № 5. -Р. 1891-1900.
246. Nillni E.A., Xie W., Mulcahy L., Sanchez V.C., Wetsel W.C. Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice // J. Biol. Chem. - 2002. - V. 277, № 50. - Р. 48587-48595.
247. Norenberg U., Richter D. Processing of the oxytocin precursor: isolation of an exopeptidase from neurosecretory granules of bovine pituitaries // Biochem. Biophys. Res. Commun. - 1988. - V. 156, № 2. - P. 898-904.
248. Novas M.L., Medina J.H., Calvo D., De Robertis E. Increase of peripheral type benzodiazepine binding sites in kidney and olfactory bulb in acutely stressed rats // Eur. J. Pharmacol. - 1987. - № 135. - Р. 243-246.
249. Nutt D.J., Malizia A.L. New insights into the role of the GABAA--benzodiazepine receptor in psychiatric disorder // The British Journal of Psychiatry. - 2001. - № 179. - Р. 390-396.
250. Obuchowicz E., Turchan J. Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum // Neuropeptides. - 1998. - V. 32, № 5. - Р. 473-480.
251. Ortego J., Escribano J., Crabb J., Coca Prados M. Identification of a neuropeptide and neuropeptide processing enzymes in aqueous humor confers neuroendocrine features to the human ocular ciliary epithelium // J. Neurochem. - 1996. - V. 66, № 2. - P. 787-796.
252. Owens G.P., Sinha A.K., Sikela J.M., Hahn W.E. Sequence and expression of the murine diazepam binding inhibitor // Brain. Res. Mol. Brain. Res. - 1989. - V. 6, № 2-3. - Р. 101-108.
253. Oyarce A.M., Hand T.A., Mains R.E., Eipper B.A. Dopaminergic regulation of secretory granule associated proteins in rat intermediate pituitary // J. Neurochem. - 1996. - V. 67, № 1. - P. 229-241.
254. Parikh V., Terry A.V., Khan M.M., Mahadik S.P. Modulation of nerve growth factor and choline acetyltransferase expression in rat hippocampus after chronic exposure to haloperidol, risperidone, and olanzapine // Psychopharmacology (Berl). - 2004. - V. 172, № 4. - Р. 365-374.
255. Parkinson D. Carboxypeptidase H in bovine pituitary gland: soluble forms are not processed at the C-terminus // Mol. Cell. Endocrinol. - 1992. - V. 86, № 3. - P. 221-233.
256. Parlow J.L., Costache I., Avery N., Turner K. Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine // Anesth. Analg. - 2004. - V. 98, № 4. - Р. 1072-1076.
257. Patterson T.A., Schulteins G., Alvarado M.C., Martinez J.L.-J.R., Bennet E.L., Rossenzweig M.R., Hruby V.Y. Influence of opioid peptides on learningand memory process in the chick // Behav.-Neurosci. - 1989. - V. 103, № 2. - P. 429-437.
258. Pelletier G. Regulation of proopiomelanocortin gene expression in rat brain and pituitary as studied by in situ hybridization // Ann NY Acad. Sci. - 1993. - № 680. - Р. 246-259.
259. Perloff M.D., Kream R.M., Beinfeld M.C. Reduced levels of substance P in the brains of Cpe(Fat)/Cpe(Fat) Mice // Peptides. - 1998. - V. 19, №6. - P. 1115-1117.
260. Persson H., Rehfeld J.F., Ericsson A., Schalling M., Pelto-Huikko M., Hokfelt T. Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization // Proc. Natl. Acad. Sci. USA. - 1989. - V. 86, № 16. - P. 6166-6170.
261. Pillot C., Ortiz J., Heron A., Ridray S., Schwartz J.C., Arrang J.M. Ciproxifan, a Histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat // The Journal of Neuroscience. - 2002. - V. 22, № 16. - P. 7272-7280.
262. Pilowsky L.S., Ring H., Shine P.J., Battersby M., Lader M. Rapid Tranquilization - A Survey of Emergency Prescribing in a General Psychiatric-Hospital // British journal of psychiatry. - 1992. - V. 160, № 6. - Р. 831-835.
263. Pivac N., Fericic D. Inhibitory Effect of Diazepam on the Activity of the Hypothalamic-Pituitary-Adrenal Axis in Female Rats // Journal of neural transmission-general section. - 1993. - V. 92, № 2-3. - Р. 173-186.
264. Polc P. Involvement of endogenous benzodiazepine receptor ligands in brain disorders: therapeutic for benzodiazepine antagonists? // Med. Hypotheses. - 1995. V. 44, № 6. - P. 439-446.
265. Porcelli G., Raffaelli R., Sacchi A., Volpe A.R., Miani C. Localization and characterization of human salivary kininases // Agents Actions Suppl. - 1992. - V. 38, № 1. - P. 401-406.
266. Powers C.A. Dopamine receptor blockade increases glandular kallikrein-like activity in the neurointermediate lobe of the rat pituitary // Biochem. Biophys. Res. Commun. - 1985. - V. 127, № 2. - Р. 668-672.
267. Prevett M.C., Lammartsma A.A., Brooks D.J., CunnighamV.I. et al. Benzodiazepine- GABAA receptor binding during absence seizures // Epilepsia. - 1995. V. 36, № 6. - P. 592-599.
268. Pritchett D.B., Roberts J.L. Dopamine regulates expression of the glandular-type kallikrein gene at the transcriptional level in the pituitary // Proc. Natl. Acad. Sci. USA. - 1987. - V. 84, № 16. - Р. 5545-5549.
269. Radke J.M., Owens M.J., Ritchie J.C., Nemeroff C.B. Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions // Neurobiology. - 1998. - V. 95, № 19. - Р. 11462-11464.
270. Rago L., Adojaan A., Pokk P. The effect of stress on 3 benzodiazepine receptor in rat blood platelets and lymphocytes: The effect of non-benzodiazepine tranquilizers // Molecular. Pharmacology of Receptors. - 1989. - V. 3. - Р. 4-16.
271. Regoli D. Toward a new anti-inflammatory and analgesic agent // PNAS. - 2000. - V. 97, № 14. - Р. 7676-7677.
272. Reimer S., Hollt V. GABAergic regulation of striatal opioid gene expression // Brain. Res. Mol. Brain. Res. - 1991. - № 1. - Р. 49-54.
273. Reymond M.J., Speciale S.G., Porter J.C. Dopamine in plasma of lateral and medial hypophysial portal vessels: evidence for regional variation in the release of hypothalamic dopamine into hypophysial portal blood // Endocrinology. - 1983. - № 112. - Р. 1958-1963.
274. Reznika S., Salafiaa С., Lageb J., Frickerc L. Localization of Carboxypeptidases E and D in the Human Placenta and Umbilical Cord // Journal of Histochemistry and Cytochemistry. - 1998. - V. 46. - Р. 1359-1368.
275. Rivier C., Rivier J., Vale W. Stress-induced inhibition of reproductive func-tions: role of endogenous CRF // Science. - 1986. - N 231. - P. 607-610.
276. Rocca P., Bellone G., Benna P., Bergamaso B., Ravizza L., Ferrero P. Peripheral-type benzodiazepine receptor and diazepam binding inhibitor-like immunoreactivity distribution in human peripheral blood mononuclear cells // Jmmunopharmacology. - 1993. - V. 25, № 2. - P. 163-178.
277. Rodriguez C., Brayton K.A., Brownstein M., Dixon J.E. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin releasing factor // J. Biol. Chem. - 1989. - V. 264, № 10. - P. 5988-5995.
278. Rossier J., Barres E., Hutton J.C., Ricknell R.J. Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes // Anal. Biochem. - 1989. - V. 178, № 1. - P. 27-31.
279. Rossier J., Battenberg E., Piffman Q. et al. Hypothalamic enkephalin neurons may regulate the neurohypophysis // Nature. - 1979. - V.277. - P.653-655.
280. Roth W.W., Mackin R.B., Spiess J., Goodman R.H., Noe B.D. Primary structure and tissue distribution of anglerfish carboxy-peptidase H // Mol. Cell. Endocrinol. - 1991. - V. 78, № 3. - P. 171-178.
281. Roubert C., Spielewoy C., Soubrie P., Hamon M., Giros B., Betancur C. Altered neurotensin mrna expression in mice lacking the dopamine transporter // Neuroscience. - 2004. - V. 123, № 2. - Р. 537-546.
282. Rouille Y., Chauvet J., Acher R. Partial conversion of vasopressinyl-Gly-Lys-Arg into pharmacologically active vasopressin through secretory granule carboxypeptidase E and alpha-amidating processing enzymes // Biochem. Int. - 1992. - V. 26, № 4. - P. 739-746.
283. Rovere C., Viale A., Nahon J., Kitabgi P. Impaired processing of brain proneurotensin and promelanin concentrating hormone in obese fat/fat mice // Endocrinology. - 1996. - V. 137, № 7. - P. 2954-2958.
284. Sands S.A., Dickerson D.S., Morris S.J., Chronwall B.M. Dopamine D2 receptor stimulation alters G-protein expression in rat pituitary intermediate lobe melanotropes // Endocrine. - 1997. - V. 6, № 3. - Р. 325-333.
285. Santarelli L., Gobbi G., Debs P.C., Sibille E.L., Blier P., Hen R., Heath M. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function // PNAS. - 2001. - V. 98, № 4. - Р. 1912-1917.
286. Schalling M., Friberg K., Riederert P. et al. Analysis of expression of cholecystokinin in dopamine cells in the ventral mesencephalon of several species and in humans with schizophrenia // Neurobiology. - 1991. - V. 87. - P. 8427-8431.
287. Schettini G., Cronin M.J., Macleod R.M. Adenosine 3',5'-monophosphate (cAMP) and calcium-calmodulin interrelation in the control of prolactin secretion: evidence for dopamine inhibition of cAMP accumulation and prolactin release after calcium mobilization // Endocrinology. - 1983. - № 112. - Р. 1801-1807.
288. Schlamp C.L., Nickells R.W. Light and dark cause a shift in the spatial ex-pression of a neuropeptide processing enzyme in the rat retina // J. Neurosci. - 1996. - V. 16, N 7. - P. 2164-2171.
289. Schremmerdanninger E., Offner A., Siebeck M., Roscher A. B1 Bradykinin Receptors and Carboxypeptidase-M Are Both Up-Regulated in the Aorta of Pigs After LPS Infusion // Biochemical and biophysical research communications. - 1998. - V. 243, № 1. - Р. 246-252.
290. Schuckit M.A., Hauger R., Klein J.L. Adrenocorticotropin Hormone Response to Diazepam in Healthy-Young Men // Biological psychiatry. - 1992. - V. 31, № 7. - Р. 661-669.
291. Seidah N.G., Chretien M. Proprotein and prohormone convertases of the subtilisin family - recent developments and future perspectives // Trends Endocrinol. Met. - 1992. - 3, № 4. - P. 133-140.
292. Sharma R.P., Janicak P.G., Bissette G., Nemeroff C.B. CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorders // Am. J. Psychiatry. - 1997. - V. 154. - Р. 1019-1021.
293. Shen F.S., Loh Y.P. Intracellular Misrouting and Abnormal Secretion of Adrenocorticotropin and Growth Hormone in Cpe (Fat) Mice Associated with a Carboxypeptidase E Mutation // Proc. Nat. Acad. Sci. USA. - 1997. - V. 94, № 10. - P. 5314-5319.
294. Shibata K., Haverstick D.M., Bannon M.J. Tachykinin gene expression in rat limbic nuclei: modulation by dopamine antagonists // J. Pharmacol. Exp. Ther. - 1990. - V. 255, № 1. - Р. 388-392.
295. Shimamori Y., Kumagai Y., Watanabe Y., Fujimoto Y. Human placental carboxypeptidase M is anchored by a glycosyl-phosphatidylinositol moiety // Biochem. Int. - 1990. - V. 20, № 3. - P. 607-613.
296. Shin C.J., Kim Y.S., Park J.B., Juhnn Y.S. Changes in G protein levels in the hippocampus and the striatum of rat brain after chronic treatment with haloperidol and sulpiride // Neuropharmacology. - 1995. - V. 34, № 10. - Р. 1335-1338.
297. Silberring J., Lason W., Przewlocka B., Przewlocki R. Enkephalin convertase in the rat spinal cord // Neuropeptides. - 1986. - V. 8, № 4. - P. 367-376.
298. Sivam S.P., Hong J.S. GABAergic regulation of enkephalin in rat striatum: alterations in Met5-enkephalin level, precursor content and preproenkephalin messenger RNA abundance // J. Pharmacol. Exp. Ther. - 1986. - V. 237, № 1. - Р. 326-331.
299. Sivam S.P., Strunk C., Smith D.R., Hong J.S. Proenkephalin-A gene regulation in the rat striatum: influence of lithium and haloperidol // Mol. Pharmacol. - 1986. - V. 30, № 2. - Р. 186-191.
300. Skidgel R., McGwire G., Li X. Membrane anchoring and release of carboxypeptidase M: implications for extracellular hydrolysis of peptide hormones. // Immunopharmacology - 1996. - V. 32, № 1-3. - Р. 48-52.
301. Skidgel R.A., Davis R.M., Tan F. Human carboxypeptidase M. Purifi-cation and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones // J. Biol. Chem. - 1989. - V. 264, № 4. - P. 2236-2241.
302. Skidgel R.A., Johnson A.R., Erdos E.G. Hydrolisys of opioid hexapeptides by carboxypeptidase N. Presence of carboxypeptidase in cell membranes // Biochem. Pharmacol. - 1984. - V. 33, № 21. - P. 3471-3478.
303. Skidgel R.A., Tan F.L., Deddish P.A., Li X.Y. Structure, function and membrane anchoring of carboxypeptidase M // Biomed. Biochim. Acta. - 1991. - V. 50, № 4-6. - P. 815-820.
304. Smith D.R., Pallen C.J., Murphy D., Lim L. Pituitary-specific transcriptional initiation sites of the rat carboxypeptidase-H gene and the influence of thyroid hormone status // Mol. Endocrinol. - 1992. - V. 6, № 5. - P. 713-722.
305. Song L.X., Fricker L.D. Calcium and pH dependent aggregation of carboxypeptidase E // J. Biol. Chem. - 1995. - 270, № 14. - P. 7963-7967.
306. Song L.X., Fricker L.D. The pro region is not required for the expression or intracellular routeing of carboxypeptidase E // Biochemical Journal. - 1997. - V. 323, № 4. - P. 265-271.
307. Srinivasan S., Bunch D.O., Feng Y., Rodriguiz R.M., Li M., Ravenell R.L., Luo G.X., Arimura A., Fricker L.D., Eddy E.M., Wetsel W.C. Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice // Endocrinology. - 2004. - V. 145, № 4. - Р. 2023-2034.
308. Stack G., Fricker L.D., Snyder S.H. A sensitive radiometric assay for enkephalin convertase and for carboxypeptidase B-like enzymes // Life Sci. - 1984. - № 34. - P. 113-121.
309. Steiner D.F. The biosynthesis of biologically active peptides: a perspective // Peptide Biosynthesis and Processing (Fricker L.D., ed.).- CRC Press, Boca Raton, Florida, 1991. - P. 1-16.
310. Strange P.G. Pathology and drug action in schizophrenia: insights from molecular biology // Essays Biochem. - 1998. - V. 33. - P. 105-116.
311. Supattapone S., Fricker L.D., Snyder S.H. Purification and characte-rization of membrane-bound enkephalin-forming carboxypeptidase, “enkephalin convertase” // J. Neurochem. - 1984. - V. 42, № 4. - P. 1017-1023.
312. Suzuki E., Shintani F., Kanba S., Asai M., Nakaki T. Induction of interleukin-1 beta and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain // Neurosci. Lett. - 1996. - V. 215, № 3. - Р. 201-204.
313. Svensson A., Carlsson M.L., Carlsson A. Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice // J. Neural. Transm. Gen. Sect. - 1995. - № 101. - Р. 127-148.
314. Sweep C.G., Boersma C.J., Wiegant V.M. Effects of chronic treatment with haloperidol and bromocriptine on the processing of beta-endorphin to gamma- and alpha-endorphin in discrete regions of the rat pituitary gland and brain // Neuropharmacology. - 1990. - V. 29, № 1. - Р. 61-68.
315. Tan F., Chan S.J., Steiner D.F., Schilling J.W., Skidgel R.A. Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N // J. Biol. Chem. - 1989. - V. 264, № 22. - P. 13165-13170.
316. Tanaka M., Tsuda A., Yokoo H., Yoshida M., Mizoguchi K., Shimizu T. Psychological stress-induced Increases in Noradrenaline Release in Rat-Brain Regions Are Attenuated by Diazepam, But Not by Morphine // Pharmacology biochemistry and behavior. - 1991. - V. 39, № 1. - Р. 191-195.
317. Tang F., Costa E., Schwartz J.P. Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks // Proc. Natl. Acad. Sci. USA. - 1983. - V. 80, № 12. - Р. 3841-3844.
318. Thiele E.A, Eipper B.A. Effect of secretagogues on components of the secretory system in AtT 20 cells // Endocrinology. - 1990. - V. 126, N 2. - P. 809-817.
319. Tong Y., Pelletier G. Role of dopamine in the regulation of proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization // Brain. Res. Mol. Brain. Res. - 1992. - V. 15, № 1-2. - Р. 27-32.
320. Tong Y., Toranzo D., Pelletier G. Localization of Diazepam-Binding Inhibitor (Dbi) Messenger-RNA in the Rat-Brain by High-Resolution Insitu Hybridization // Neuropeptides. - 1991. - V. 20, № 1. - Р. 33-40.
321. Turalba A.V., Leite-Morris K.A., Kaplan G.B. Antipsychotics regulate cyclic AMP-dependent protein kinase and phosphorylated cyclic AMP response element-binding protein in striatal and cortical brain regions in mice // Neurosci. Lett. - 2004. - V. 357, № 1. - Р. 53-57.
322. Vallar L., Meldolesi J. Mechanisms of signal transduction at the dopamine D2 receptor // Trends. Pharmacol. Sci. - 1989. - V. 10, № 2. - Р. 74-77.
323. Van Ree J.M., Gaffori O., De Wied D. In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents // Eur. J. Pharmacol. - 1983. - V. 93, № 1-2. - Р. 63-78.18-21
324. Vargas M.A., Bourdais J., Sanchez S., Uriostegui B., Moreno E., Josephbravo P., Charli J.L. Multiple hypothalamic factors regulate pyroglutamyl peptidase-II in Cultures of adenohypophyseal cells - role of the cAMP pathway // J. Neuroendocrinol. - 1998. - V. 10, N 3. - P. 199-206.
325. Vetulani J. Pharmacological receptors: the membrane receptors for neurotransmitters and drugs // Acta. Physiol. Pol. - 1988. - V. 39, № 2. - Р. 81-97.
326. Wallace E.F., Evans C.J., Jurik, S.M., Mettord I.N., Barchas J.D. Carboxypeptidase B activity from adrenal medulla - is it involved in the processing of proenkephalin // Life Sci. - 1982. - 31, № 16-17. - P. 1793-1796.
327. Wang H., Li S., Givalois L., Pelletier G. Influence of adrenal glands on the modulation of prolactin gene expression by the endogenous benzodiazepine ligand octadecaneuropeptide in the male rat pituitary gland // J. Neuroendocrinol. - 1998. - V. 10, № 3. - Р. 193-198.
328. Wang Y., Goldman-Rakic P.S. D2 receptor regulation of synaptic burst firing in prefrontal cortical pyramidal neurons // Proc. Natl. Acad. Sci. USA. - 2004. - V. 101, № 14. - Р. 5093-5098.
329. Waters S.M., Rounseville M.P., Davis T.P. Effect of dopaminergic drugs on processing and degradative neuropeptidase mRNA in rat frontal cortex and caudate-putamen // Brain. Res. - 1997. - V. 754, № 1-2. - Р. 28-34.
330. Wilson M.A., Biscardi R., Smith M.D., Wilson S.P. Effects of benzodiazepine agonist exposure on corticotropin-releasing factor content and hormonal stress responses: divergent responses in male and ovariectomized female rats // J. Pharmacol. Exp. Ther. - 1996. - V. 278, № 3. - Р. 1073-1082.
331. Xu J.H., Liu H.C., Zhang Y.P. 4-Aminopyridine Induced Rage Reaction in Mice // ACTA PHARMACOLOGICA SINICA. - 1991. - V. 12, № 2. - Р. 155-159.
332. Yoshikawa K., Hong J.S. The enkephalin system in the rat anterior pituitary: regulation by gonadal steroid hormones and psychotropic drugs // Endocrinology. - 1983. - V. 113, № 4. - Р. 1218-1227.
333. Yoshioka S., Fujiwara H., Yamada S., Nakayma T., Higuchi T., Inoue T., Mori T., Maeda M. Membrane-Bound Carboxypeptidase-M Is Expressed on Human Ovarian Follicles and Corpora-Lutea of Menstrual-Cycle and Early-Pregnancy // Molecular Human Reproduction. - 1998. - V. 4, № 7. - P. 709-717.
334. Zachrisson O., Nomikos G.G., Marcus M.M., Svensson T.H., Lindefors N. Effects of antipsychotic drugs on cholecystokinin and preprotachykinin (substance P) mRNA expression in the rat hippocampal formation // Eur. Neuropsychopharmacol. - 2000. - V. 10, № 5. - Р. 355-363.
335. Zahm D.S., Williams E.S., Poulad D., Krause J.E. Temporal dissociation of neurotensin/neuromedin N mRNA expression in topographically separate subsets of rat striatal neurons following administration of haloperidol // Brain. Res. Mol. Brain Res. - 1996. - V. 42, № 1. - Р. 71-78.
336. Zetler G. Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8) // Neuropharmacology. - 1980. - V. 19, № 5. - Р. 415-422.
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